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BIBTEX RIS

Evaluation of the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex

2017; Elsevier BV; Volume: 92; Linguagem: Inglês

10.1016/j.biopha.2017.06.020

ISSN

1950-6007

Autores

Fernanda de Sousa Oliveira, Thiago Sampaio de Freitas, Rafael Pereira da Cruz, Maria do Socorro Costa, Raimundo Luíz Silva Pereira, Lucindo José Quintans‐Júnior, Tatianny de Araújo Andrade, Paula dos Passos Menezes, Bruna Maria Hipólito de Sousa, Paula Santos Nunes, Mairim Russo Serafini, Irwin Rose Alencar de Menezes, Adriano Antunes de Souza Araújo, Henrique Douglas Melo Coutinho,

Tópico(s)

Drug Transport and Resistance Mechanisms

Resumo

The present study aimed to evaluate the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex. The minimum inhibitory concentration was determined through the broth microdilution technique using the bacterial strains: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The drugs norfloxacin, imipenem and gentamicin were used in the tests, and the compounds α-bisabolol and β-cyclodextrin; all the compounds were diluted in DMSO. To obtain the minimum inhibitory concentration (MIC) a serial microdilution of the substances in volumes corresponding to the sub-inhibitory concentration (MIC/8), and microdilution with the antibiotic until the penultimate well were performed. The results showed that β-cyclodextrin did not present synergistic effects when combined with the antibiotics. It was found that α-bisabolol presented a synergistic effect against S. aureus, when combined with the antibiotic norfloxacin. Moreover, α-bisabolol presented synergism against E. coli when combined with gentamicin. The results of this study show that α-bisabolol presents a modulatory synergistic effect for some antibiotics, as gentamicin, and this is an interesting result against multidrug resistant bacteria (MDR). By other side, the complexation of α-bisabolol with β-cyclodextrin apparently reduces the modulatory effect, maybe due the polarity enhancement of the polarity of α-bisabolol, affecting the interaction of this compound with the cell membrane bilayer. However, more studies are necessary to demonstrate or not these interactions.

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