Portal de Periódicos da CAPES

Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)

2017; Royal Society of Chemistry; Volume: 53; Issue: 54 Linguagem: Inglês

10.1039/c7cc03879h

1364-548X

Caroline M. Robb, Jacob I. Contreras, Smit Kour, Margaret Taylor, Mohammad Abid, Yogesh A. Sonawane, Muhammad Zahid, Daryl J. Murry, Amarnath Natarajan, Sandeep Rana,

CAR-T cell therapy research

In this manuscript, for the first time, we report the synthesis of a PROTAC that selectively degrades cyclin dependent kinase 9 (CDK9).