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Antibiotic Resistance as a Stress Response: Recovery of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus “Auxiliary” ( fem ) Mutants by Induction of the Stringent Stress Response

2017; American Society for Microbiology; Volume: 61; Issue: 8 Linguagem: Inglês

10.1128/aac.00313-17

1098-6596

Choon Kim, Catarina Milheiriço, Hermı́nia de Lencastre, Alexander Tomasz,

Bacterial biofilms and quorum sensing

Studies with methicillin-resistant Staphylococcus aureus (MRSA) strain COL have shown that the optimal resistance phenotype requires not only mecA but also a large number of "auxiliary genes" identified by Tn551 mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-MICs of mupirocin, suggesting that the mechanism of reduced resistance in the auxiliary mutants involved the interruption of a stringent stress response, causing reduced production of penicillin-binding protein 2A (PBP 2A).