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Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

2017; Oxford University Press; Volume: 65; Issue: 5 Linguagem: Inglês

10.1093/cid/cix406

1537-6591

Vanessa Raabe, Gerrit Kann, Bruce S. Ribner, Andrés Morales, Jay B. Varkey, Aneesh K. Mehta, G. Marshall Lyon, Sharon Vanairsdale, Kelly Faber, Stephan Becker, Markus Eickmann, Thomas Strecker, Shelley Brown, Ketan Patel, Philipp de Leuw, Gundolf Schuettfort, Christoph Stephan, Holger F. Rabenau, John D. Klena, Pierre E. Rollin, Anita K. McElroy, Ute Ströher, Stuart T. Nichol, Colleen S. Kraft, Timo Wolf, Sonia Bell, Catherine Maloney, Pam Cosper, Nancye Feistritzer, John M. Lewin, Bryce Gartland, Ira Horowitz, David Pugh, Chad W.M. Ritenour, Jerry P. Lewis, D. M. Hatcher, Linda Scott-Harris, Lynne Ometer, K J Hardy, Jeff Broughton, Robert Jackson, Samantha Thomas, Toni Ash, Christopher O. Barnes, Jamie Breedlove, Bob Bridgman, Lane Darragh, Tracey Daye, Dustin Hillis, Crystal H Johnson, J.E. Johnson, Danni LaFond, Courtney Lyons, Josia Mamora, Anna McCord, Samantha McDaniel, Haley Morgan, Jill S. Morgan, Alexander Sanchez, Marissa Simon, Jason Slabach, Kevin Tirado, Sally Watkins, Terrica Wilson, Ken Logan, J R Buchanan, Eileen M. Burd, John F. Cardella, Brenda L. Eaves, Crystal Evans, Charles E. Hill, Doris Igwe, Karen Jenkins, Maureen Lindsey, Jordan Magee, Stacy McCarthy, Randall K. Powers, James Ritchie, Jan Pack, Susan Rogers, Patricia Olinger, K Rengarajan, Scott W. Thomaston, Esmeralda Meyer, Emily Beck, Paula DesRoches, Cynthia R Hall, Celeste Walker, Esther Baker, Betsy Hackman, Jeff Broughton, Robert Jackson, Jerry P. Lewis, Robin Brown-Haithco, Faith Richardson, Art Krasilovsky, C. Jordan, Sue Matthews, Marilyn Hazzard Lineberger, Paula G Gomes, Gentrice McGee, Porcia Jones, Linda Scott-Harris, James Cain, Roderick W. Davis, Tyrone Johnson, Tyrone Pickett, Anthony Shaw, Tenina Truesdale, A. N. Isakov, Sam Shartar, Wade Miles, Aaron Jamison, John Arévalo, Gail Stallings, Janet Christenbury, Vince Dollard, Melanie De Gennaro, Holly Korschun, Tom Ziegler, Daniel Griffith, Nisha Davé,

Viral Infections and Vectors

Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir. Both patients survived but developed transaminitis and had prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmission of Lassa virus should be considered.