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T cells from patients with Parkinson’s disease recognize α-synuclein peptides

2017; Nature Portfolio; Volume: 546; Issue: 7660 Linguagem: Inglês

10.1038/nature22815

1476-4687

David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Côté, Ellen Kanter, Julian Agin‐Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth J. Phillips, S. Mallal, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette,

Nuclear Receptors and Signaling

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.