HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
2017; Springer Science+Business Media; Volume: 27; Issue: 4 Linguagem: Inglês
10.1016/j.bjp.2017.05.003
ISSN1981-528X
AutoresJhon Castañeda-Gómez, Daniel Rosas-Ramírez, Sara E. Cruz-Morales, Mabel Fragoso‐Serrano, Rogelio Pereda‐Miranda,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoHigh performance liquid chromatography profiling with mass spectrometry detection was applicable to identify known and novel multidrug-resistance glycolipid inhibitors from the complex resin glycosides mixture of Ipomoea alba L., Convolvulaceae, seeds. Albinosides X and XI were purified by recycling liquid chromatography and their structural elucidation was accomplished by nuclear magnetic resonance. Albinoside XI exerted a strong potentiation of vinblastine susceptibility in multidrug-resistant human breast carcinoma cells.
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