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Regulation of eye derived growth factor binding to membranes by light, ATP or GTP in photoreceptor outer segments.

1988; Springer Nature; Volume: 7; Issue: 2 Linguagem: Inglês

10.1002/j.1460-2075.1988.tb02823.x

1460-2075

Jean Plouët, Frédéric Mascarelli, M. D. Loret, Jean‐Pierre Faure, Yves Courtois,

Retinoids in leukemia and cellular processes

Research Article1 February 1988free access Regulation of eye derived growth factor binding to membranes by light, ATP or GTP in photoreceptor outer segments. J. Plouët J. Plouët INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author F. Mascarelli F. Mascarelli INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author M. D. Loret M. D. Loret INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author J. P. Faure J. P. Faure INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author Y. Courtois Y. Courtois INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author J. Plouët J. Plouët INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author F. Mascarelli F. Mascarelli INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author M. D. Loret M. D. Loret INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author J. P. Faure J. P. Faure INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author Y. Courtois Y. Courtois INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. Search for more papers by this author Author Information J. Plouët1, F. Mascarelli1, M. D. Loret1, J. P. Faure1 and Y. Courtois1 1INSERM U 86, Centre Biomédical des Cordeliers, Paris, France. The EMBO Journal (1988)7:373-376https://doi.org/10.1002/j.1460-2075.1988.tb02823.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Eye derived growth factor II (EDGF II), the retinal form of acidic fibroblast growth factor (aFGF) is present in rod outer segments (ROS) purified in the dark, which display higher EDGF specific activity than all other parts of the retina. EDGF binds to ROS disc membranes upon illumination. This binding is not reversible in the dark. ATP, but not GTP, readily releases EDGF from either dark-adapted or previously bleached ROS. The release of EDGF activity from ROS membranes would require a phosphorylation mechanism since AMP-PNP, an ATP analogue, is not efficient. ROS membranes compete with cellular EDGF receptors of retinal pigment epithelial cells in vitro for the binding of labelled EDGF II, suggesting that they also possess specific binding sites. These data suggest that EDGF II is involved in photoreceptor cell biology. Previous ArticleNext Article Volume 7Issue 21 February 1988In this issue RelatedDetailsLoading ...