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Endothelial cell metabolism in health and disease: impact of hypoxia

2017; Springer Nature; Volume: 36; Issue: 15 Linguagem: Inglês

10.15252/embj.201696150

1460-2075

Brian W. Wong, Elke Marsch, Lucas Treps, Myriam Baes, Peter Carmeliet,

Cancer, Lipids, and Metabolism

In contrast to the general belief, endothelial cell (EC) metabolism has recently been identified as a driver rather than a bystander effect of angiogenesis in health and disease. Indeed, different EC subtypes present with distinct metabolic properties, which determine their function in angiogenesis upon growth factor stimulation. One of the main stimulators of angiogenesis is hypoxia, frequently observed in disease settings such as cancer and atherosclerosis. It has long been established that hypoxic signalling and metabolism changes are highly interlinked. In this review, we will provide an overview of the literature and recent findings on hypoxia-driven EC function and metabolism in health and disease. We summarize evidence on metabolic crosstalk between different hypoxic cell types with ECs and suggest new metabolic targets.