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Human fatal yellow fever

1992; Elsevier BV; Volume: 188; Issue: 1-2 Linguagem: Inglês

10.1016/s0344-0338(11)81176-3

1618-0631

Thales de Brito, Sheila Aparecida Coelho Siqueira, Raimunda TM Santos, E.S. Nassar, Terezinha Lisieux Moraes Coimbra, Venâncio Avancini Ferreira Alves,

Vibrio bacteria research studies

An immunobistochemical method to detect yellow fever antigen was developed using immune sera from rabbits and hamsters and byperimmune ascitic fluid from mice. A search for the antigen was carried out in liver, kidney and heart in three fatal cases of yellow fever. In the liver it was present in the cytoplasm of bepatocytes, Councilman bodies and Kupffer cells. Yellow fever antigen was also detected in renal tubular epithelium and in groups of myocardial fibers. These findings suggest that viral replication occurs at sites other than the liver. Since yellow fever shares many features with other baemorrbagic fevers the use of immunobistochemistry can impart a significant improvement in the accuracy of its bistopatb o logical diagnosis.