RNA-Binding Proteins in Cancer: Old Players and New Actors
2017; Elsevier BV; Volume: 3; Issue: 7 Linguagem: Inglês
10.1016/j.trecan.2017.05.003
ISSN2405-8033
AutoresBruno Pereira, Marc Billaud, Raquel Almeida,
Tópico(s)RNA and protein synthesis mechanisms
ResumoRNA-binding proteins (RBPs) are key players in post-transcriptional events. The combination of versatility of their RNA-binding domains with structural flexibility enables RBPs to control the metabolism of a large array of transcripts. Perturbations in RBP-RNA networks activity have been causally associated with cancer development, but the rational framework describing these contributions remains fragmented. We review here the evidence that RBPs modulate multiple cancer traits, emphasize their functional diversity, and assess future trends in the study of RBPs in cancer.
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