The Fluorescent Polydiacetylene Liposome
2003; Wiley; Volume: 24; Issue: 5 Linguagem: Inglês
10.5012/bkcs.2003.24.5.667
ISSN1229-5949
AutoresEun Kyung Ji, Dong June Ahn, Jong Man Kim,
Tópico(s)Supramolecular Self-Assembly in Materials
ResumoDevelopment of efficient sensors utilizing conjugated polymer as sensing matrices has gained much attention among many research scientists.1-11Especially, polydiacetylene (PDA)-based sensors for the detection of biologically important species have been intensively investigated due to the unique color changing properties upon stimulation.12-27Closely packed and properly designed certain diacetylenes can undergo polymerization via 1,4-addition reaction to form an ene-yne alternated polymer chain upon UV irradiation with 254 nm as shown in Figure 1.28-35The resulting polydiacetylenes, if obtained under optimized conditions, appear to be intense blue color to the naked eyes.The blue-colored polydiacetylenes can be prepared in the form of liposomes in aqueous solutions or as thin films using Langmuir-Blodgett or Langmuir-Schaefer methods.The advantage of the nanostructured polydiacetylenes as biosensors comes from the fact that visible color change from blue to red occur in response to a variety of environmental pertur bations, such as temperature,36-39 pH,40 and ligand-receptor interactions.12-14,27Many researchers have tried to understand the mechanism of the color transition.Although it is not clear, it has widely been accepted that color change is associated with a conformational change of polydiacetylene backbone.Accordingly, the polydiacetylenes in the blue form have extended conjugation of p-orbital in the main chain of the polymers.The conjugated p-orbitals undergo distortion by environmental stimuli, leading to partial twist (Ri 드 functionalized alkyl chain, R2 그 alkyl chain)
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