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Identity of Gli1+ cells in the bone marrow

2017; Elsevier BV; Volume: 54; Linguagem: Inglês

10.1016/j.exphem.2017.06.349

1873-2399

Isadora F. G. Sena, Pedro H. D. M. Prazeres, Gabryella S. P. Santos, Isabella T. Borges, Patrick O. Azevedo, Julia P. Andreotti, Viviani Mendes de Almeida, Ana Paiva, Daniel Guerra, Luiza Lousado, Luanny Souto, Akiva Mintz, Alexander Birbrair,

Mesenchymal stem cell research

Highlights•Bone marrow Gli1+ cells are heterogeneous at their location within the bone marrow.•Gli1+ cells provide a central cellular target in bone marrow fibrosis.•Gli1+ cells act as bone marrow mesenchymal stem cells.AbstractBone marrow fibrosis is a critical component of primary myelofibrosis in which normal bone marrow tissue and blood-forming cells are gradually replaced with scar tissue. The specific cellular and molecular mechanisms that cause bone marrow fibrosis are not understood. A recent study using state-of-the-art techniques, including in vivo lineage tracing, provides evidence that Gli1+ cells are the cells responsible for fibrotic disease in the bone marrow. Strikingly, genetic depletion of Gli1+ cells rescues bone marrow failure and abolishes myelofibrosis. This work introduces a new central cellular target for bone marrow fibrosis. The knowledge that emerges from this research will be important for the treatment of several malignant and nonmalignant disorders.