Produção Nacional
Células-tronco de pluripotência induzida: progressos em animais domésticos
2017; Volume: 39; Issue: 3 Linguagem: Inglês
ISSN
1809-3000
AutoresARACY AMARAL, Danilo Barbosa Coimbra, Natalia Gonçalves, Carlos Eduardo Ambrósio,
Tópico(s)CRISPR and Genetic Engineering
ResumoThe use of pluripotent stem cells is a promising opportunity for the treatment of degenerative diseases that have no cure. The use of those is limited by ethics and biosafety arguments. Takahashi e Yamanaka (2006) developed an alternative that allows the obtainment of pluripotent stem cells from adult cells by induction with specific transcription factors (Yamanaka factors). Such discovery created a way to avoid the questions about embryo destruction also, created the possibility of autologous transplantation decreasing problems related to biosafety. The process for obtaining (iPSC) is also studied in Veterinary Medicine field in order to validate several experimental in domestic and production models. Above that, it is an alternative to create a genomic bank of endangered species. Nervethless there are many differences on protocols and results obtained hindering the efficiency and effectiveness of the studies in this area. This work presents a detailed review about what was effective or not on the processes of obtaining iPSCs in canine, feline, equine, bovine and swine until this moment.
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