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BIBTEX RIS

Portraying the oddness of autism: My name is Khan; Indian Sesame street

2017; Elsevier BV; Volume: 30; Linguagem: Inglês

10.1016/j.ajp.2017.07.008

ISSN

1876-2026

Autores

Suravi Patra,

Tópico(s)

Child Development and Digital Technology

Resumo

Toll Like Receptor (TLR) family plays an important role in the activation of innate immunity against pathogens. TLR7 mediates the recognition of single-stranded RNA viruses, such as human immunodeficiency virus, hepatitis C virus, and influenza virus in endosomes. Here, we generated a TLR7 homozygous knockout human induced pluripotent cell (hiPSC) line, hiPSC-TLR7KO-A59, using the CRISPR/Cas9 genome editing method. The hiPSC-TLR7KO-A59 line maintains normal morphology, pluripotency, and differentiation capacity into three germ layers.

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