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Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression

2017; Hindawi Publishing Corporation; Volume: 2017; Issue: 1 Linguagem: Inglês

10.1155/2017/7865073

1942-0900

Deborah Bauer, Danielle dos Santos Bonfim De Castro, Felipe Leite de Oliveira, Eduardo Matos Nogueira, Marco Antônio Mota da Silva, Anderson Junger Teodoro,

Plant-Derived Bioactive Compounds

Breast cancer is one of the most prevalent cancers in the world and is also the leading cause of cancer death in women. The use of bioactive compounds of functional foods contributes to reduce the risk of chronic diseases, such as cancer and vascular disorders. In this study, we evaluated the antioxidant potential and the influence of pitaya extract (PE) on cell viability, colony formation, cell cycle, apoptosis, and expression of BRCA 1 , BRCA 2 , PRAB, and Er α in breast cancer cell lines (MCF‐7 and MDA‐MB‐435). PE showed high antioxidant activity and high values of anthocyanins (74.65 ± 2.18). We observed a selective decrease in cell proliferation caused by PE in MCF‐7 (ER + ) cell line. Cell cycle analysis revealed that PE induced an increase in G 0 /G 1 phase followed by a decrease in G 2 /M phase. Also, PE induced apoptosis in MCF‐7 (ER + ) cell line and suppressed BRCA 1 , BRCA 2 , PRAB, and Er α gene expression. Finally, we also demonstrate that no effect was observed with MDA‐MB‐435 cells (ER − ) after PE treatment. Taken together, the present study suggests that pitaya may have a protective effect against breast cancer.