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EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET

2017; Elsevier BV; Volume: 1868; Issue: 2 Linguagem: Inglês

10.1016/j.bbcan.2017.06.006

1879-2561

Steven Goossens, Niels Vandamme, Pieter Van Vlierberghe, Geert Berx,

FOXO transcription factor regulation

Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly accepted as a core component of carcinoma progression. Collectively, EMT and transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the same breath for nearly 20 years. Recent work on these EMT-TFs has extended their scope, and their typical definition as EMT-inducing factors has become out-of-date. New insights have warranted a re-evaluation of these transcription factors and their pleiotropic functions in physiological and pathological conditions, not solely limited to cell invasion and dissemination.