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Evidence for scale up: the differentiated care research agenda

2017; International AIDS Society; Volume: 20; Issue: S4 Linguagem: Inglês

10.7448/ias.20.5.22024

1758-2652

Anna Grimsrud, Ruanne V. Barnabas, Peter Ehrenkranz, Nathan Ford,

Healthcare Policy and Management

Journal of the International AIDS SocietyVolume 20, Issue S4 22024 EditorialOpen Access Evidence for scale up: the differentiated care research agenda Anna Grimsrud, Corresponding Author Anna Grimsrud anna.grimsrud@iasociety.org HIV Programmes & Advocacy, International AIDS Society, Cape Town, South AfricaCorresponding author: Anna Grimsrud, International AIDS Society, Cape Town 7708, South Africa. Tel: +27 78 129 7304. (anna.grimsrud@iasociety.org)Search for more papers by this authorRuanne V. Barnabas, Ruanne V. Barnabas Departments of Global Health and Medicine, University of Washington, Seattle, USASearch for more papers by this authorPeter Ehrenkranz, Peter Ehrenkranz Department of Global Development, Bill & Melinda Gates Foundation, Seattle, WA, USASearch for more papers by this authorNathan Ford, Nathan Ford Department of HIV/AIDS & Global Hepatitis Programme, World Health Organization, Geneva, SwitzerlandSearch for more papers by this author Anna Grimsrud, Corresponding Author Anna Grimsrud anna.grimsrud@iasociety.org HIV Programmes & Advocacy, International AIDS Society, Cape Town, South AfricaCorresponding author: Anna Grimsrud, International AIDS Society, Cape Town 7708, South Africa. Tel: +27 78 129 7304. (anna.grimsrud@iasociety.org)Search for more papers by this authorRuanne V. Barnabas, Ruanne V. Barnabas Departments of Global Health and Medicine, University of Washington, Seattle, USASearch for more papers by this authorPeter Ehrenkranz, Peter Ehrenkranz Department of Global Development, Bill & Melinda Gates Foundation, Seattle, WA, USASearch for more papers by this authorNathan Ford, Nathan Ford Department of HIV/AIDS & Global Hepatitis Programme, World Health Organization, Geneva, SwitzerlandSearch for more papers by this author First published: 21 July 2017 https://doi.org/10.7448/IAS.20.5.22024Citations: 78 Funding for this supplement was provided by the Bill & Melinda Gates Foundation. AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat “It's not about everybody getting the same thing. It's about everybody getting what they need in order to improve the quality of their situation.” Cynthia Silvia Parker, Interaction Institute for Social Change. The scale up of antiretroviral therapy (ART) to more than 18 million people living with HIV (PLHIV) [1], primarily in low- and middle-income countries, is one of history's greatest public health achievements. Life expectancy among PLHIV on ART has improved worldwide [2], and in some settings hardest hit by the epidemic, rapid gains have been seen. For example, in KwaZulu-Natal, South Africa, life expectancy has increased three times faster than the previous highest recorded increase – seen in Japan as it recovered from World War II [3]. Advances in treatment over the past decade combined with increased access to care have transformed HIV into a manageable, chronic disease [4]. HIV has led the way in providing a platform that could lead to the successful management of chronic diseases in resource-limited settings [5,6]. We now live in an era where it is recommended that all PLHIV initiate ART as soon as possible following diagnosis [7], and consequently the size of the potential treatment cohort has almost doubled, from 18.2 million to 36.7 million [1,8]. However, global funding for the epidemic remains flat or declining in present-day value [9,10]. With the cost of antiretroviral drugs having decreased 100-fold in the past decade [11], further cost reductions are dependent on making “efficiency gains” within the healthcare system. However, what about the client – the person living with HIV? While there is evidence of high rates of attrition after starting ART [12], among those who do stay on treatment, high levels of viral suppression are achieved [13,14]. Yet, as the world pushes towards 90–90–90 targets, the resources being utilized to achieve the current successes will be further stretched and known challenges, like rates of attrition, may be exacerbated. Business as usual will not be enough to meet global treatment goals. However, much of the success of ART scale up to date has been attributed to its simple, one-size-fits-all approach [15] in which most PLHIV receive facility-based care from professional healthcare cadres at frequent intervals regardless of their context, clinical characteristics or subpopulation. Differentiated care or differentiated service delivery is defined as “a client-centred approach that simplifies and adapts HIV services across the cascade, in ways that both serve the needs of PLHIV better and reduce unnecessary burdens on the health system” [16]; it is an attempt to maintain a public health approach while acknowledging that people's needs change over time. The majority of published evidence of differentiated care has been limited to ART delivery for stable adults in high-prevalence settings in sub-Saharan Africa. Largely pioneered by the medical aid agency Médecins Sans Frontières (MSF), four innovative service delivery models have emerged in response to context-specific client needs and health systems challenges met in different countries [17]: Client-managed groups (known as community adherence groups or CAGs) in Mozambique to address the limitation of a supply chain that could only provide one month of ART refills at a time to PLHIV who lived far from the facilities [18–20]. This model has been researched in Haiti [21], Lesotho [22], Malawi, South Africa and Zambia with implementation in Uganda (as community client-led ART delivery or CCLAD) and national policy support for scale up in Kenya, Swaziland [23] and Zimbabwe. Healthcare worker-managed groups (known as adherence clubs) in South Africa to address high client volumes and long wait times [24,25]. This model has national policy support for scale up in Kenya [26] (as facility-based distribution groups), Swaziland [23] (as facility-based treatment clubs) and Zimbabwe (as club refills). Pilot implementation is ongoing in the Democratic Republic of the Congo (DRC) and Zambia (as adherence groups). Facility-based individual models (known as the six-monthly appointment or SMA programme) in Malawi to address long wait times at facilities in a context where three-monthly ART refills were included in national guidelines, and six-monthly clinical visits could be piloted [27,28]. This model has been piloted or implemented in at least six other countries (Ethiopia, Rwanda, South Africa, Swaziland, Uganda [29] and Zimbabwe) and is commonly referred to as fast-track or multi-month prescription/scripting. Out-of-facility individual models (known as points de distribution communautaires or PODIs) in the DRC to reduce client costs of transport to clinics and fees for clinic visits [17,30]. Out-of-facility individual models include: mobile outreach (being implemented in Namibia and Swaziland [23]); community drug distributions points (CDDPs) as seen in Uganda [31,32]); the central chronic medicine dispensing and distribution (CCMDD) programme in South Africa; and home-delivery. These four basic models are proposed as a common nomenclature for describing differentiated care for stable ART clients. For this special issue of the Journal of the International AIDS Society, we issued a global call for abstracts on differentiated care with the aim of deepening the understanding of these approaches and broadening the knowledge base. In this editorial, we present 10 priority areas for investigation, highlighting areas where manuscripts in the supplement have made contributions and noting gaps that remain. These priority research areas are informed by an appraisal of the literature and discussions with representatives from networks of people living with HIV, ministries of health, implementing partners, researchers, normative agencies and funders. 1. Beyond the context of sub-Saharan Africa and high-prevalence settings Two articles by MSF highlight examples of differentiated ART delivery outside of sub-Saharan Africa. Mesic et al. report on the client and health system implications of an individual facility-based model for stable clients in Yangon, Myanmar [33]. Their findings present novel evidence of the success of differentiated ART delivery for stable clients in a concentrated HIV epidemic. Work from South Sudan, the Central African Republic and the DRC is shared in the article by Ssonko et al., differentiating ART services both for ART initiation and delivery, were implemented to support client outcomes in challenging environments [34]. Finally, a commentary by Nsanzimana et al. on the phased implementation of an individual facility-based model in the Rwandan national HIV programme emphasizes the relevance of differentiated ART delivery in Rwanda [35], a low-prevalence HIV setting [36,37]. With the exception of limited pilot data from Haiti [21], the three articles in this supplement are the first to assess how differentiated care can be advantageous in different contexts. What is the role and the impact of differentiated care in contexts of low prevalence and low coverage? 2. Beyond stable adults: impact for key and vulnerable populations Differentiated care does not only mean ART delivery for stable clients, despite the majority of the evidence coming from this approach. Potentially, those who stand to benefit the most from a differentiated care approach are the key and vulnerable populations who do not access routine clinic care and may require more attention to achieve quality HIV care outcomes. Macdonald and colleagues make a strong argument for the inclusion of key populations – men who have sex with men, transgender people, people who use drugs and persons in closed settings – within differentiated care [38]. Limited data on ART outcomes among key populations are available, with the majority of funding and programming for this group targeted at the front end of the HIV care cascade (i.e. HIV testing and prevention). Given the structural barriers, including criminalization and stigma that adversely impact key populations from accessing and receiving quality care, the question of whether differentiated care can mitigate these barriers is raised. As “treat all” is being implemented globally, there are a number of lessons to be learned from the implementation of Option B+ for pregnant women. A large body of evidence highlights the poor rates of retention among women who are initiated onto ART during pregnancy. In the article by Myer et al, the six-month post-partum outcomes of women who are initiated during pregnancy are reported after their self-selection into a healthcare worker-managed group (community adherence clubs) or referral to their local primary care clinic [39]. While the study is limited in reporting of outcomes (the study could not assess if women referred to but not retained in adherence clubs were retained on other ART services), it draws attention to the reality that PLHIV may benefit from different service delivery models throughout their treatment lifetime. Clearly, more research for both pregnant women and key populations is required – as is more work focusing on children, adolescents and young people, men and other marginalized populations. Can differentiated care engage and retain those populations who are currently not in the clinic-based HIV care system? 3. Beyond pilots: overall impact Public health authorities often seek evidence that new models of care have proved to be feasible, acceptable, cost efficient and effective outside of research settings; yet such “real-life” evaluations of programmes that have achieved partial or full scale are rare. The programme evaluation of 30 high-volume facilities in Malawi providing different models of care alongside traditional models by Prust et al. was a response to a ministry request for an independent assessment of ongoing programmes [40]. It augmented routinely collected clinical data with data on health systems costs, as well as PLHIV and healthcare provider experience, to provide the policymakers with the evidence to guide policy decisions. Tsondai et al. assessed outcomes of clients in the healthcare worker-managed adherence clubs in the Western Cape of South Africa, with a random sample of 10% of clients from non-research supported sites [41]. With high rates of retention and viral suppression, this evidence confirms that good outcomes among patients differentiated into a healthcare worker-managed groups are not limited to pilot projects. Additional programme evaluations, cohort studies, step wedge or other smart implementation science designs are needed to bolster evidence for the benefits of differentiated care at scale. Outcomes measures should include retention in care, viral suppression, data on patient and healthcare worker experience, healthcare worker productivity, as well as health system and patient costs. What will be the “real-life” outcomes when models are scaled, such as the streamlined delivery model presented by Kwarisiima et al. [42]? What is the best strategic mix of models to achieve optimal outcomes in a given setting? 4. Cost – for the health system and also for clients While the primary purpose of differentiated care is to improve patient outcomes and not to save costs, donor funding for HIV programmes is declining. Costing of these models is therefore important to inform choice by national governments and advocate for donor support for scale up. Such costing work is complicated and should be expanded to include the health systems costs inclusive of training and implementation and the client costs (e.g. transportation, missed opportunity/work). Implementation of differentiated care approaches is facilitated by access to viral load monitoring, and previous modelling suggests that the costs of viral load monitoring can be offset by taking action on results to refer clients with high viral loads to intensified clinical care or shift the engagement of those with suppressed viral load to a reduced frequency of visits [43]. In the article noted above, Prust et al. describe evidence of such costs among three different models of care in Malawi [40]. Adding to previously published evidence on cost [19,29,32,44–48], Barker et al. suggest that differentiated care models could decrease health systems costs in 38 countries in sub-Saharan Africa [49]. While some costing work has been done, an additional benefit of costing may be identifying areas for efficiencies. What are the clients’ costs (including time spent waiting or in transit) when engaged in a differentiated model of care vs. a traditional model? Which models lead to the greatest increase in health care worker productivity and make the best use of existing infrastructure? 5. Differentiated care across the cascade The concept of differentiated care is applicable across the care cascade from prevention to testing to viral suppression. While the majority of studies in this issue are limited to the provision of ART, an article from Uganda by Asiimwe et al. provides evidence that lay cadres can be leveraged to expand testing services and supporting linkage of PLHIV to care [50]. Many unanswered questions remain with respect to how to improve outcomes at the front end of the cascade. What service delivery models can be used to improve testing, linkage and initiation of ART? And can we leverage the models of differentiated ART delivery to support this? For example, can we use community-based client-managed group members to increase rates of testing and linkage [51,52]? Can ART initiation be included within models of community testing? And with regards to prevention, what service delivery models will work to improve access, uptake and adherence to pre-exposure prophylaxis (PrEP)? 6. Evidence for extending refills The review from Apollo et al. summarizes the evidence base used by the World Health Organization to make its 2016 recommendations of 3–6 monthly clinical visits and 3–6 monthly ART refills for stable clients [7,53]. Can these intervals be widened, and do they apply to all populations? In South Africa, clinical consultations for stable clients on ART are annual and so analyzing national routine data may support extending the frequency of clinic visits. Further, for children who are 2–5 years of age, the misconception of frequent dosing changes (which mainly occur in the first year) has led to an insistence on frequent clinic visits. And for adolescents, there is desire for frequent visits and contact given their high rates of attrition, despite the evidence that frequent clinic visits leads to higher rates of loss to care among adults. Similarly, there is an assumption that someone who appears to be non-adherent requires additional contact with the health system. Can we define which segments of people – shift workers, students in a full day of school – are most likely to experience frequent visits as a barrier to adherence? The remaining four research priorities are not addressed within this special issue, and this may reflect an overall lack of evidence and experience in these domains. These include client and healthcare worker preference, integration of co-interventions, integration of care for co-morbidities and co-infections, and assessing the impact of differentiated care for clinically unstable patients (e.g. clients with high viral load, uncontrolled comorbidity, etc.). 7. Client choice, satisfaction and quality If the client is at the centre, then the client's voice must be central to the design of differentiated care. When assessing which model(s) to choose, it is fundamental to speak with the clients or recipients of care [54]. Further, for differentiated care to become integrated within healthcare systems, there will also need to be perceived benefits for healthcare workers. Is there a correlation between implementation of differentiated care, decreased costs, improved quality and improvements in client and healthcare worker experience? 8. Integration of co-interventions within HIV differentiated care HIV services cannot operate as vertical programmes. If differentiated care is to be successful, models will need to integrate co-interventions. How can HIV self-testing, PrEP isoniazid preventive therapy, cotrimoxazole and other prophylaxis plus simple diagnostic tests (e.g. Lipoarabinomannan or LAM assays to detect TB), be integrated into service delivery models? 9. Integration of care for co-morbidities and co-infections within HIV differentiated care The design of service delivery models for PLHIV must also address co-morbidities and co-infections [26]. With an aging population of PLHIV and a burgeoning epidemic of chronic diseases, services must incorporate treatment and prevention for non-communicable diseases. In addition, integration of tuberculosis services, provision of family planning and availability of opioid substitution therapy are all necessary to realize a client-centred approach. Evidence is needed on the leading causes of morbidity and mortality among HIV-positive persons on ART to indicate which services to integrate with HIV care. How can co-morbidities be integrated with HIV differentiated care? 10. Impact of differentiated care for clinically unstable clients Can clients with high viral loads benefit from being included in differentiated ART delivery models? For example, can community delivery of ART to those most at risk of defaulting lead to improved outcomes? Does the implementation of differentiated ART delivery for stable clients lead to an efficient refocusing of clinic resources towards improved outcomes for those who are unstable? And how can we establish and strengthen community referral to ensure that clients who need intensified clinical support are accessing services in a timely manner? Conclusions The evidence base to support differentiated care is robust and expanding, but many questions remain. Overarching these priority areas for research is the engagement of local policymakers, implementers and PLHIV in the development of a prioritization plan, the design of the studies and the full dissemination of results to support demand creation for differentiated care services within their communities and among healthcare workers. Differentiated care has the potential to be a game changer in the treat all era [55], but will only realize its full potential with scaled implementation and ongoing adaptation informed by implementation research. Competing interests None of the authors have any competing interests to declare. Disclaimer The views and opinions expressed here are solely those of the authors in their private capacity. The contents in this document are those of the authors and do not necessarily reflect the views of the Bill & Melinda Gates Foundation. Biography The concept for this developed by AG, RB, PE and NF. AG wrote the first draft. All authors contributed and approved the final version. References 1 UNAIDS. Get on the fast-track - The life-cycle approach to HIV. Geneva: UNAIDS; 2016. 2Wandeler G, Johnson LF, Egger M. Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: comparisons with general population. Curr Opin HIV AIDS. 2016; 11(5): 492– 500. 3Reniers G, Slaymaker E, Nakiyingi-Miiro J, Nyamukapa C, Crampin AC, Herbst K, et al. Mortality trends in the era of antiretroviral therapy: evidence from the network for analysing longitudinal population-based HIV/AIDS data on Africa (ALPHA). Aids. 2014; 28(Suppl 4): S533– 42. 4Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet. 2013; 382(9903): 1525– 33. 5Abrams EJ, El-Sadr WM. Lessons from Harlem: relevance to a global epidemic. J Acquir Immune Defic Syndr. 2009; 52(Suppl 1): S24– 6. 6Harries AD, Zachariah R, Jahn A, Schouten EJ, Kamoto K. Scaling up antiretroviral therapy in Malawi-implications for managing other chronic diseases in resource-limited countries. J Acquir Immune Defic Syndr. 2009; 52(Suppl 1): S14– 6. 7 World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. 2nd ed. Geneva, Switzerland: WHO; 2016. 8 UNAIDS. Global AIDS update 2016. Geneva: UNAIDS; 2016. 9Kates J, Wexler A, Lief E. Financing the response to HIV in low- and middle-income countries: international assistance from donor governments in 2015. Washington, DC and Geneva: Kaiser Family Foundation & UNAIDS 2015; 2016. 10Lancet HIV. HIV funding key for sustainable development. The Lancet HIV. 2016; 3(11): e499. 11 Médecins Sans Frontières. Untangling the web of antiretroviral price reductions. 18th ed. Geneva, Switzerland: Médecins Sans Frontières; 2016. 12Fox MP, Rosen S. Retention of adult patients on antiretroviral therapy in low- and middle-income countries: systematic review and meta-analysis 2008-2013. J Acquir Immune Defic Syndr. 2015; 69(1): 98– 108. 13Maman D, Chilima B, Masiku C, Ayouba A, Masson S, Szumilin E, et al. Closer to 90-90-90. The cascade of care after 10 years of ART scale-up in rural Malawi: a population study. J Int AIDS Soc. 2016; 19(1): 20673. 14Justman JE, Hoos D, Kalton G, Nyirenda R, Moyo C, Mugurungi O, et al. Real progress in the HIV epidemic: PHIA findings from Zimbabwe, Malawi and Zambia. Paper presented at: Conference on Retroviruses and Opportunistic Infections (CROI) 2017; 2017; Seattle, USA. 15Gilks CF, Crowley S, Ekpini R, Gove S, Perriens J, Souteyrand Y, et al. The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings. Lancet. 2006; 368(9534): 505– 10. 16Grimsrud A, Bygrave H, Doherty M, Ehrenkranz P, Ellman T, Ferris R, et al. Reimagining HIV service delivery: the role of differentiated care from prevention to suppression. J Int AIDS Soc. 2016; 19(1): 21484. 17Bemelmans M, Baert S, Goemaere E, Wilkinson L, Vandendyck M, van Cutsem G, et al. Community-supported models of care for people on HIV treatment in sub-Saharan Africa. Trop Med Int Health. 2014; 19(8): 968– 77. 18Decroo T, Telfer B, Biot M, Maikere J, Dezembro S, Cumba LI, et al. Distribution of antiretroviral treatment through self-forming groups of patients in Tete province, Mozambique. J Acquir Immune Defic Syndr. 2011; 56(2): e39– 44. 19Rasschaert F, Decroo T, Remartinez D, Telfer B, Lessitala F, Biot M, et al. Adapting a community-based ART delivery model to the patients’ needs: a mixed methods research in Tete, Mozambique. BMC Public Health. 2014; 14(1): 364. 20Decroo T, Koole O, Remartinez D, Dos Santos N, Dezembro S, Jofrisse M, et al. Four-year retention and risk factors for attrition among members of community ART groups in Tete, Mozambique. Trop Med Int Health. 2014; 19(5): 514– 21. 21Naslund JA, Dionne-Odom J, Junior Destine C, Jogerst KM, Renold Senecharles R, Jean Louis M, et al. Adapting and Implementing a community program to improve retention in care among patients with HIV in Southern Haiti: “Group of 6”. AIDS Res Treat. 2014; 2014: 137545. 22Vandendyck M, Motsamai M, Mubanga M, Makhakhe S, Tunggal S, Jonckheree S, et al. Community-based ART resulted in excellent retention and can leverage community empowerment in rural Lesotho, a mixed method study. HIV/AIDS Res Treat Open J. 2015; 2(2): 44– 50. 23Pasipamire L, Kerschberger B, Zabsonre I, Ndlovu S, Sibanda G, Mamba S, et al. Rapid implementation of combination ART refill models in rural Swaziland. Paper presented at: 21st International AIDS Conference (AIDS 2016); 2016; Durban, South Africa. 24Luque-Fernandez MA, van Cutsem G, Goemaere E, Hilderbrand K, Schomaker M, Mantangana N, et al. Effectiveness of patient adherence groups as a model of care for stable patients on antiretroviral therapy in Khayelitsha, Cape Town, South Africa. PLoS One. 2013; 8(2): e56088. 25Wilkinson L, Harley B, Sharp J, Solomon S, Jacobs S, Cragg C, et al. The expansion of the Adherence Club model for stable antiretroviral therapy patients in the Cape Metro, South Africa 2011-2015. Trop Med Int Health. 2016; 21(6): 743– 49. 26Khabala KB, Edwards JK, Baruani B, Sirengo M, Musembi P, Kosgei RJ, et al. Medication Adherence Clubs: a potential solution to managing large numbers of stable patients with multiple chronic diseases in informal settlements. Trop Med Int Health. 2015; 20(10): 1265– 70. 27McGuire M, Pedrono G, Mukhuna B, Huckabee M, Heinzelmann A, Szumilin E, et al. Optimizing patient monitoring after the first year of ART: three years of implementing 6-monthly clinical appointments in rural Malawi. Paper present at: AIDS 2014; 2014; Melbourne, Australia. 28Cawley C, Nicholas S, Szumilin E, Perry S, Amoros Quiles I, Masiku C, et al. Six-monthly appointments as a strategy for stable antiretroviral therapy patients: evidence of its effectiveness from seven years of experience in a Medecins Sans Frontieres supported programme in Chiradzulu district. Paper presented at: Malawi 21st International AIDS Conference (AIDS 2016); 2016; Durban, South Africa. 29Alamo ST, Wagner GJ, Ouma J, Sunday P, Marie L, Colebunders R, et al. Strategies for optimizing clinic efficiency in a community-based antiretroviral treatment programme in Uganda. AIDS Behav. 2013; 17(1): 274– 83. 30Vogt F, Kalenga L, Lukela J, Salumu F, Diallo I, Nico E, et al. Brief report: decentralizing ART supply for stable HIV patients to community-based distribution centers: program outcomes from an urban context in Kinshasa, DRC. J Acquir Immune Defic Syndr. 2017; 74(3): 326– 31. 31Okoboi S, Ding E, Persuad S, Wangisi J, Birungi J, Shurgold S, et al. Community-based ART distribution system can effectively facilitate long-term program retention and low-rates of death and virologic failure in rural Uganda. AIDS Res Ther. 2015; 12: 37. 32Jaffar S, Amuron B, Foster S, Birungi J, Levin J, Namara G, et al. Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial. Lancet. 2009; 374(9707): 2080– 89. 33Mesic A, Fontaine J, Aye T, Greig J, Thwe TT, Moretó-Planas L, et al. Implications of differentiated care for successful ART scale-up in a concentrated HIV epidemic in Yangon, Myanmar. J Int AIDS Soc. 2017; 20 (Suppl 4): 21644. 34Ssonko CGL, Mesic A, Silveira Da Fonseca M, Achar J, Safar N, Martin B, et al. Delivering HIV care in challenging operating environments: the MSF experience towards differentiated models of care for settings with multiple basic health care needs. J Int AIDS Soc. 2017; 20(Suppl 4): 21654. 35Nsanzimana SRE, Ribakare M, Burns T, Dludlu S, Mills EJ, Condo J, et al. Phased implementation of spaced clinic visits for stable HIV-positive patients in Rwanda to support Treat All. J Int AIDS Soc. 2017; 20(Suppl 4): 21635. 36 UNAIDS. Rwanda HIV and AIDS estimates. Geneva: UNAIDS; 2015 [cited 2017 Apr]; Available from: http://www.unaids.org/en/regionscountries/countries/rwanda 37Lu C, Chin B, Lewandowski JL, Basinga P, Hirschhorn LR, Hill K, et al. Towards universal health coverage: an evaluation of Rwanda Mutuelles in its first eight years. PLoS One. 2012; 7(6): e39282. 38MacDonald V, Verster A, Baggaley R. A call for differentiated approaches to delivering HIV services to key populations. J Int AIDS Soc. 2017; 20(Suppl 4): 21658. 39Myer LLV, Zerbe A, Philips TK, Brittain K, Mukonda E, Allerton J, et al. Differentiated models of care for HIV-infected postpartum women receiving antiretroviral therapy in Cape Town, South Africa: a cohort study. J Int AIDS Soc. 2017; 20(Suppl 4): 21636. 40Prust MLBC, Nyirenda R, Chimbwandira F, Kalua T, Jahn A, Eliya M, et al. Multi-month prescriptions, fast-track refills, and community ART groups: results from a process evaluation in Malawi on using differentiated models of care to achieve national HIV treatment goals. J Int AIDS Soc. 2017; 20(Suppl 4): 21650. 41Tsondai PR, Wilkinson LS, Grimsrud A, Mdlalo PT, Ullauri A, Boulle A. High rates of retention and viral suppression in the scale-up of antiretroviral rherapy adherence clubs in Cape Town, South Africa. J Int AIDS Soc. 2017; 20 (Suppl 4): 21649. 42Kwarisiima DKM, Owaraganise A, Mwangwa F, Byonanebye DM, Ayieko J, Plenty A, et al. High rates of viral suppression in adults and children with high CD4+ counts using a streamlined ART delivery model in the SEARCH trial in rural Uganda and Kenya. J Int AIDS Soc. 2017; 20 (Suppl 4): 21673. 43Phillips A, Shroufi A, Vojnov L, Cohn J, Roberts T, Ellman T, et al. Sustainable HIV treatment in Africa through viral-load-informed differentiated care. Nature. 2015; 528(7580): S68– 76. 44Bango F, Ashmore J, Wilkinson L, van Cutsem G, Cleary S. Adherence clubs for long-term provision of antiretroviral therapy: cost-effectiveness and access analysis from Khayelitsha, South Africa. Trop Med Int Health. 2016; 21 (9): 1115– 23. 45Rasschaert F, Telfer B, Lessitala F, Decroo T, Remartinez D, Biot M, et al. A qualitative assessment of a community antiretroviral therapy group model in Tete, Mozambique. PLoS One. 2014; 9(3): e91544. 46Babigumira JB, Castelnuovo B, Stergachis A, Kiragga A, Shaefer P, Lamorde M, et al. Cost effectiveness of a pharmacy-only refill program in a large urban HIV/AIDS clinic in Uganda. PLoS One. 2011; 6(3): e18193. 47Jakubowski A, Kabami J, Mwai D, Snyman K, Clark T, Ayieko J, et al. Provision of streamlined HIV care associated with reduced economic burden of care-seeking among HIV-infected adults. 21st International AIDS Conference (AIDS 2016); 2016; Durban, South Africa. 48Vu L, Waliggo S, Zieman B, Jani N, Buzaalirwa L, Okoboi S, et al. Annual cost of antiretroviral therapy among three service delivery models in Uganda. J Int AIDS Soc. 2016; 19(5 Suppl 4): 20840. 49Barker CDA, Klein K. Can differentiated care models solve the crisis in HIV treatment financing? Analysis of prospects for 38 countries in sub-Saharan Africa. J Int AIDS Soc. 2017; 20(Suppl 4): 21648. 50Asiimwe SRJ, Arinaitwe A, Tumusiime O, Turyamureeba B, Roberts DA, O'Malley G, et al. Expanding HIV testing and linkage to care in southwestern Uganda with community health extension workers. J Int AIDS Soc. 2017; 20 (Suppl 4): 21633. 51Simons E, Ellman T, Giuliani R, Bimansha C, Das Dores C, Mosse Lázaro TP, et al. Reaching the first 90: index case HIV testing and the role of a community model of care in Tete, Mozambique. Paper presented at: 21st International AIDS Conference (AIDS 2016); 2016; Durban, South Africa. 52Simons E, Ellman T, Giuliani R, Mosse Lázaro TP, Nassiaca R. Moving towards the second 90: linkage to care and the role of a community model of care in Tete, Mozambique. Paper presented at: 21st International AIDS Conference (AIDS 2016); 2016; Durban, South Africa. 53Mutasa-Apollo T, Ford N, Wiens M, Socias ME, Negussie E, Wu P, Popoff E, et al. Effect of frequency of clinic visits and medication pick-up on antiretroviral treatment outcomes: a systematic literature review and meta-analysis. J Int AIDS Soc. 2017; 20(Suppl 4). 54 AIDS Rights Alliance of Southern Africa (ARASA) & International Treatment Preparedness Coalition (ITPC). Differentiated models of delivering HIV care: Perspectives from people living with HIV and health care workers in 7 African Countries; 2016; South Africa. 55 South African Department of Health, Council SANA. Let our actions count: South Africa's national strategic plan on HIV, TB and STIs 2017-2022. South Africa: South African National AIDS Council (SANAC); 2017. Citing Literature Volume20, IssueS4Differentiated care & HIVJuly 201722024 ReferencesRelatedInformation