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Immobilized copper ions on MWCNTS-Chitosan thin film: Enhanced amperometric sensor for electrochemical determination of diclofenac sodium in aqueous solution

2017; Elsevier BV; Volume: 42; Issue: 31 Linguagem: Inglês

10.1016/j.ijhydene.2017.06.163

1879-3487

Md. Shalauddin, Shamima Akhter, Samira Bagheri, Mohd Sayuti Abd Karim, Nahrizul Adib Kadri, Wan Jefrey Basirun,

Electrochemical Analysis and Applications

A simple and effective electrochemical sensor was designed by the drop cast method for the detection of Diclofenac Sodium (DS), a widely used painkiller, by combining the significant catalytic property of multi-walled carbon nanotubes (MWCNTs), excellent adsorption capacity and film forming ability of Chitosan and synergistic catalytic effect of Chitosan-copper complex. The characteristics of newly proposed composite (MWCNTs/CTS-Cu/GCE) were investigated by different techniques like Fourier Transform Infrared Spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM) and Energy dispersive X-ray analysis (EDX). The electrochemical performance of the newly modified composite was studied by using Cyclic voltammetry (CV), Electrochemical impedance spectroscopy (EIS), Square wave voltammetry (SWV). Under the optimum conditions, the anodic peak current for Diclofenac sodium (DS) was linear and the range is between 0.3 and 200 μmol L−1 with the detection limit of 0.021 μmol L−1 at pH 4.0. Finally, this modified composite exhibit good selectivity, sensitivity and stability for the detection of Diclofenac sodium (DS) from the pharmaceutical dosage form and real samples.