Tinzaparin in cancer associated thrombosis beyond 6 months: TiCAT study
2017; Elsevier BV; Volume: 157; Linguagem: Inglês
10.1016/j.thromres.2017.07.004
ISSN1879-2472
AutoresLuis Jara‐Palomares, Aurora Solier-López, Teresa Elías-Hernández, María Isabel Asensio-Cruz, Isabel Blasco-Esquivias, Lucía Marín-Barrera, Maria Rodriguez de la Borbolla-Artacho, Juan Manuel Praena‐Fernández, Emilio Montero-Romero, Silvia Navarro‐Herrero, María Pilar Serrano-Gotarredona, José María Sánchez-Díaz, Carlos Palacios, Remedios Otero,
Tópico(s)Heparin-Induced Thrombocytopenia and Thrombosis
ResumoIntroductionThe safety and efficacy of low-molecular-weight heparin (LMWH) treatment in patients with cancer-associated thrombosis (CAT) beyond 6 months are unknown. Our aim was to determine the safety of long-term tinzaparin use in patients with CAT.MethodsWe performed a prospective, open, single arm, multicentre study in patients with CAT receiving treatment with tinzaparin. We evaluated the rate of clinically relevant bleeding events (major and non-major clinically relevant bleeding) and venous thromboembolism (VTE) recurrence.ResultsA total of 247 patients were recruited, with a crude incidence of major bleeding of 4.9% (12/247). The rate of clinically relevant bleeding during months 1–6 and 7–12, was 0.9% [95% confidence interval (95% CI) 0.5 to 1.6%] and 0.6% (95% CI 0.2 to 1.4%) (p = 0.5) per patient and month, respectively. Male gender showed greater risk for clinically relevant bleeding with a hazard ratio (HR) of 2.97 (95% CI 1.01 to 8.1; p = 0.02). The incidence of VTE recurrence at months 1–6 and 7–12 was 4.5% (95% CI 2.2 to 7.8%) and 1.1% (95% CI 0.1 to 3.9%), respectively. One patient died due to VTE recurrence and two because of severe bleeding.ConclusionsTreatment with tinzaparin beyond 6 months is safe in patients with CAT.
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