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Selective Palladium(II)‐Catalyzed Carbonylation of Methylene β‐C−H Bonds in Aliphatic Amines

2017; Wiley; Volume: 56; Issue: 39 Linguagem: Inglês

10.1002/anie.201706303

1521-3773

Jaime R. Cabrera‐Pardo, Aaron Trowbridge, Manuel Nappi, Kyohei Ozaki, Matthew J. Gaunt,

Cyclopropane Reaction Mechanisms

Palladium(II)-catalyzed C-H carbonylation reactions of methylene C-H bonds in secondary aliphatic amines lead to the formation of trans-disubstituted β-lactams in excellent yields and selectivities. The generality of the C-H carbonylation process is aided by the action of xantphos-based ligands and is important in securing good yields for the β-lactam products.