Produção Nacional
Revisado por pares
Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New “Leave Me Alone” Lesion with a Characteristic Imaging Pattern
2017; American Society of Neuroradiology; Volume: 38; Issue: 10 Linguagem: Inglês
10.3174/ajnr.a5281
ISSN1936-959X
AutoresRenato Hoffmann Nunes, Charlie Hsu, Antônio José da Rocha, Lázaro Luís Faria do Amaral, Luís Filipe de Souza Godoy, Trevor Watkins, Victor Hugo Rocha Marussi, Monika Warmuth‐Metz, Heitor Alves, Fabrício Guimarães Gonçalves, Bette K. Kleinschmidt‐DeMasters, Anne G. Osborn,
Tópico(s)Cerebrospinal fluid and hydrocephalus
ResumoSUMMARY: Multinodular and vacuolating neuronal tumor of the cerebrum is a recently reported benign, mixed glial neuronal lesion that is included in the 2016 updated World Health Organization classification of brain neoplasms as a unique cytoarchitectural pattern of gangliocytoma. We report 33 cases of presumed multinodular and vacuolating neuronal tumor of the cerebrum that exhibit a remarkably similar pattern of imaging findings consisting of a subcortical cluster of nodular lesions located on the inner surface of an otherwise normal-appearing cortex, principally within the deep cortical ribbon and superficial subcortical white matter, which is hyperintense on FLAIR. Only 4 of our cases are biopsy-proven because most were asymptomatic and incidentally discovered. The remaining were followed for a minimum of 24 months (mean, 3 years) without interval change. We demonstrate that these are benign, nonaggressive lesions that do not require biopsy in asymptomatic patients and behave more like a malformative process than a true neoplasm.
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