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Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity

2017; Cold Spring Harbor Laboratory Press; Volume: 31; Issue: 12 Linguagem: Inglês

10.1101/gad.300079.117

1549-5477

Ciro Zanca, Genaro R. Villa, Jorge A. Benítez, Amy Haseley Thorne, Tomoyuki Koga, Matteo D’Antonio, Shiro Ikegami, Jianhui Ma, Antonia Boyer, Afsheen Banisadr, Nathan M. Jameson, Alison D. Parisian, Olesja Eliseeva, Gabriela F. Barnabé, Feng Liu, Sihan Wu, Huijun Yang, Jill Wykosky, Kelly A. Frazer, Vladislav V. Verkhusha, Maria Isaguliants, William A. Weiss, Timothy C. Gahman, Andrew K. Shiau, Clark C. Chen, Paul S. Mischel, Webster K. Cavenee, Frank B. Furnari,

Cytokine Signaling Pathways and Interactions

Ciro Zanca1, Genaro R. Villa1,2,3, Jorge A. Benitez1, Amy Haseley Thorne1, Tomoyuki Koga1, Matteo D'Antonio4, Shiro Ikegami1, Jianhui Ma1, Antonia D. Boyer1, Afsheen Banisadr1, Nathan M. Jameson1, Alison D. Parisian1, Olesja V. Eliseeva5, Gabriela F. Barnabe1, Feng Liu1,6,7,8, Sihan Wu1, Huijun Yang1, Jill Wykosky1, Kelly A. Frazer4,9,10, Vladislav V. Verkhusha11, Maria G. Isaguliants5,12,13, William A. Weiss14,15,16, Timothy C. Gahman1, Andrew K. Shiau1, Clark C. Chen4, Paul S. Mischel1,4,17, Webster K. Cavenee1,4,18 and Frank B. Furnari1,4,17 1Ludwig Institute for Cancer Research, La Jolla, California 92093, USA; 2Department of Molecular and Medical Pharmacology, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA; 3Medical Scientist Training Program, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA; 4Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA; 5Gamaleya Research Center of Epidemiology and Microbiology, Moscow 123098, Russian Federation; 6National Research Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 7State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 8Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 9Institute for Genomic Medicine, University of California at San Diego, La Jolla, California 92093, USA; 10Department of Pediatrics, Rady Children's Hospital, Division of Genome Information Sciences, University of California at San Diego, La Jolla, California 92093, USA; 11Department of Anatomy and Structural Biology, Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA; 12Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Stockholm 17177, Sweden; 13Department of Research, Riga Stradins University, Riga LV-1007, Latvia; 14Department of Neurology, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94159, USA; 15Department of Pediatrics, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94159, USA; 16Department of Neurosurgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94159, USA; 17Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA; 18Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA Corresponding author: ffurnari{at}ucsd.edu