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BIBTEX RIS

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

2017; Lippincott Williams & Wilkins; Volume: 70; Issue: 3 Linguagem: Inglês

10.1161/hypertensionaha.117.09438

1524-4563

Louise V. Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, A. Mesut Erzurumluoglu, Paul F. O’Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose, Germaine C. Verwoert, Jouke‐Jan Hottenga, Rona J. Strawbridge, Tõnu Esko, Dan E. Arking, Shih-Jen Hwang, Xiuqing Guo, Zoltán Kutalik, Stella Trompet, Nick Shrine, Alexander Teumer, Janina S. Ried, Joshua C. Bis, Albert V. Smith, Najaf Amin, Ilja M. Nolte, Leo‐Pekka Lyytikäinen, Anubha Mahajan, Nicholas J. Wareham, Edith Hofer, Peter K. Joshi, Kati Kristiansson, Michela Traglia, Aki S. Havulinna, Anuj Goel, Mike A. Nalls, Siim Sõber, Dragana Vuckovic, Jian’an Luan, Fabiola Del Greco M, Kristin L. Ayers, Jaume Marrugat, Daniela Ruggiero, Lorna M. Lopez, Teemu Niiranen, Stefan Enroth, Anne Jackson, Christopher P. Nelson, Jennifer E. Huffman, Weihua Zhang, Jonathan Marten, Ilaria Gandin, Sarah E. Harris, Tatijana Zemunik, Yingchang Lu, Εvangelos Εvangelou, Nabi Shah, Martin H. de Borst, Massimo Mangino, Bram P. Prins, Archie Campbell, Ruifang Li‐Gao, Ganesh Chauhan, Christopher Oldmeadow, Gonçalo Abecasis, Maryam Abedi, Caterina Barbieri, Michael R. Barnes, Chiara Batini, John Beilby, Tineka Blake, Michael Boehnke, Erwin P. Böttinger, Peter S. Braund, Morris J. Brown, Marco Brumat, Harry Campbell, John C. Chambers, Massimiliano Cocca, Francis S. Collins, John Connell, Heather J. Cordell, Jeffrey Damman, Gail Davies, Eco J. C. de Geus, Renée de Mutsert, Joris Deelen, Yusuf Demirkale, Alex S. F. Doney, Marcus Dörr, Martin Farrall, Teresa Ferreira, Mattias Frånberg, He Gao, Vilmantas Giedraitis, Christian Gieger, Franco Giulianini, Alan J. Gow, Anders Hamsten, Tamara B. Harris, Albert Hofman, Elizabeth G. Holliday, Jennie Hui, Marjo‐Riitta Järvelin, Åsa Johansson, Andrew D. Johnson, Jari Lahti, Antti Jula, Mika Kähönen, Sekar Kathiresan, Kay‐Tee Khaw, Ivana Kolčić, Seppo Koskinen, Claudia Langenberg, Marty Larson, Lenore J. Launer, Benjamin Lehne, David C. Liewald, Li Lin, Lars Lind, François Mach, Chrysovalanto Mamasoula, Cristina Menni, Borbála Mifsud, Yuri Milaneschi, Anna Morgan, Andrew D. Morris, Alanna C. Morrison, Peter J. Munson, Priyanka Nandakumar, Quang Tri Nguyen, Teresa Nutile, Albertine J. Oldehinkel, Ben A. Oostra, Elin Org, Sandosh Padmanabhan, Aarno Palotie, Guillaume Paré, Alison Pattie, Brenda W.J.H. Penninx, Neil R Poulter, Peter P. Pramstaller, Olli T. Raitakari, Meixia Ren, Kenneth Rice, Paul M. Ridker, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Jerome I. Rotter, Igor Rudan, Yasaman Saba, Aude Saint Pierre, Cinzia Sala, Antti-Pekka Sarin, Reinhold Schmidt, Rodney J. Scott, Marc A. Seelen, Denis C. Shields, David S. Siscovick, Rossella Sorice, Alice Stanton, David J. Stott, Johan Sundström, Morris A. Swertz, Kent D. Taylor, Simon Thom, Ioanna Tzoulaki, Christophe Tzourio, André G. Uitterlinden, Uwe Völker, Péter Vollenweider, Philipp S. Wild, Gonneke Willemsen, Alan F. Wright, Jie Yao, Sébastien Thériault, David Conen, John Attia, Peter Sever, Stéphanie Debette, Dennis O. Mook‐Kanamori, Eleftheria Zeggini, Tim D. Spector, Pim van der Harst, Nicholette D. Palmer, Anne‐Claire Vergnaud, Ruth J. F. Loos, Ozren Polašek, John M. Starr, Giorgia Girotto, Caroline Hayward, Jaspal S. Kooner, Cecilia M. Lindgren, Véronique Vitart, Nilesh J. Samani, Jaakko Tuomilehto, Ulf Gyllensten, Paul Knekt, Ian J. Deary, Marina Ciullo, Roberto Elosúa, Bernard Keavney, Andrew A. Hicks, Robert A. Scott, Paolo Gasparini, Maris Laan, Yongmei Liu, Hugh Watkins, Catharina A. Hartman, Veikko Salomaa, Daniela Toniolo, Markus Perola, James F. Wilson, Helena Schmidt, Wei Zhao, Terho Lehtimäki, Cornelia M. van Duijn, Vilmundur Guðnason, Bruce M. Psaty, Annette Peters, Rainer Rettig, Anthony James, J. Wouter Jukema, David P. Strachan, Walter Palmas, Andres Metspalu, Erik Ingelsson, Dorret I. Boomsma, Oscar H. Franco, Murielle Bochud, Christopher Newton‐Cheh, Patricia B. Munroe, Paul Elliott, Daniel I. Chasman, Aravinda Chakravarti, Jo Knight, Andrew P. Morris, Daniel Levy, Martin D. Tobin, Harold Snieder, Mark J. Caulfield, Georg Ehret,

Hormonal Regulation and Hypertension

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project–based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7 , TNXB , LRP12 , LOC283335 , SEPT9 , and AKT2 , and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA . Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.