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Influence of childhood trauma on diagnosis and substance use in first-episode psychosis

2017; Cambridge University Press; Volume: 211; Issue: 3 Linguagem: Inglês

10.1192/bjp.bp.116.194019

1472-1465

Simona Tomassi, Sarah Tosato, Valeria Mondelli, Carlo Faravelli, Antonio Lasalvia, Giulia Fioravanti, Chiara Bonetto, Angelo Fioritti, Cleber Cremonese, Riccardo Lo Parrino, Katia De Santi, Anna Meneghelli, Stefano Torresani, Giovanni de Girolamo, E. Semrov, Michela Pratelli, Doriana Cristofalo, Mirella Ruggeri,

Prenatal Substance Exposure Effects

Background Childhood trauma has been significantly associated with first-episode psychosis, affective dysfunction and substance use. Aims To test whether people with first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increased lifetime rate of substance use. Method The sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d.=9.7). Results Severe sexual abuse was significantly associated with a diagnosis of affective psychosis (χ 2 =4.9, P =0.04) and with higher rates of lifetime use of cannabis (68% v. 41%; P = 0.02) and heroin (20% v. 5%; P =0.02). Severe physical abuse was associated with increased lifetime use of heroin (15% v. 5%; P = 0.03) and cocaine (32% v. 17%; P = 0.05). Conclusions Patients with first-episode psychosis exposed to childhood trauma appear to constitute a distinctive subgroup in terms of diagnosis and lifetime substance use.