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EASI‐IMS an expedite and secure technique to screen for 25I‐NBOH in blotter papers

2017; Wiley; Volume: 52; Issue: 10 Linguagem: Inglês

10.1002/jms.3977

1096-9888

Damila Rodrigues de Morais, Ingrid Lopes Barbosa, Kelly Francisco da Cunha, Guilherme L. Tripodi, Célio Fernando Figueiredo Angolini, Marcos Fernando Franco, Elvis Medeiros de Aquino, Marcos N. Eberlin, José Luiz Costa,

Forensic Toxicology and Drug Analysis

Abstract The increasing number of new psychoactive substances (NPS) and their quick worldwide spreading, often only slightly modified in the form of new derivatives and analogues, have brought the need for fast, wide‐ranging, and unequivocal identification methods in clinical and forensic investigations. Because it usually provides secure results, gas chromatography coupled to mass spectrometry (GC‐MS) has been routinely employed as the standard technique for the detection of NPS in blotter papers. For 25I‐NBOH (N‐(2‐hydroxybenzyl)‐2‐(4‐iodo‐2,5‐dimethoxyphenyl)ethan‐1‐aminium), however, GC‐MS analysis of an blotter paper extract leads to incorrect results. In this work, we investigated whether easy ambient sonic‐spray mass spectrometry imaging (EASI‐IMS), and ambient ionization MS method can be applied directly to the surface of the sample requiring therefore no extraction or sample preparations, would serve as an efficient, sensitive, and secure alternative for 25I‐NBOH screening.