In vivo demonstration of the suitability of piezoelectric stimuli for bone reparation
2017; Elsevier BV; Volume: 209; Linguagem: Inglês
10.1016/j.matlet.2017.07.099
ISSN1873-4979
AutoresClarisse Ribeiro, Daniela M. Correia, Ilda Rodrigues, L. Guardão, Sérgio Augusto Catanzaro Guimarães, Raquel Soares, S. Lanceros‐Méndez,
Tópico(s)Electrospun Nanofibers in Biomedical Applications
ResumoThe potential of piezoelectric biomaterials for bone tissue engineering is demonstrated. This work proves that the use of piezoelectric poly(vinylidene fluoride) (PVDF), able to provide electrical stimuli upon mechanical solicitation to the growing cells, enhances bone regeneration in vivo. Poled and non-poled β-PVDF films and randomly oriented electrospun fiber mats have been used to test their osteogenic properties in Wistar rats by analyzing new bone formation in vivo. After 4 weeks, defect implanted with poled β-PVDF films demonstrated significantly more defect closure and bone remodeling, showing the large potential of piezoelectric biomaterials for bone repair.
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