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BIBTEX RIS

Antibacterial activity of extract and fractions from branches of Protium spruceanum and cytotoxicity on fibroblasts

2017; Taylor & Francis; Volume: 32; Issue: 16 Linguagem: Inglês

10.1080/14786419.2017.1354182

ISSN

1478-6427

Autores

Tatiane Roquete Amparo, Ivanildes Vasconcelos Rodrigues, Janaína Brandão Seibert, Rafaella Hilda Zaniti Souza, Amanda Ribeiro de Oliveira, Vivette Appolinário Rodrigues Cabral, Paula Melo de Abreu Vieira, Geraldo Célio Brandão, Adriana Akemi Okuma, Sidney Augusto Vieira Filho, Luiz Fernando de Medeiros Teixeira, Gustavo Henrique Bianco de Souza,

Tópico(s)

Plant-derived Lignans Synthesis and Bioactivity

Resumo

The crude ethanol extract (CEE) and fractions from branches of Protium spruceanum were subjected to antibacterial and cytotoxicity assays. Compounds of the most active fraction were identified by GC-MS and LC-MS. CEE was active against 19 bacteria and the ethyl acetate fraction (EAF) showed the lowest minimum bactericidal concentration (MBC 0.3–80.0 mg/mL). Through time-kill assay was observed that EAF induced rapid bactericidal effect against Staphylococcus saprophyticus. The cytotoxicity tests against L929 fibroblasts showed great potential of EAF on the treatment of infections caused by five bacteria (MBC < IC50). The results provide in vitro scientific support to the possible application of branches of P. spruceanum as antimicrobial agent that may contribute for treatment of infections.

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