Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy
2017; Bentham Science Publishers; Volume: 16; Issue: 5 Linguagem: Inglês
10.2174/1570159x15666170720095240
ISSN1875-6190
Autores Tópico(s)Neurological Disease Mechanisms and Treatments
ResumoAlzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the progressive loss of neurons, which typically leads to severe impairments in cognitive functions including memory and learning. Key pathological features of this disease include the deposition of highly insoluble amyloid β peptides and the formation of neurofibrillary tangles (NFTs) in the brain. Mounting evidence also implicates sustained glial-mediated inflammation as a major contributor of the neurodegenerative processes and cognitive deficits observed in AD.
Referência(s)