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Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

2017; American Association for the Advancement of Science; Volume: 357; Issue: 6355 Linguagem: Inglês

10.1126/science.aal4677

1095-9203

Shai Bel, Mihir Pendse, Yuhao Wang, Yun Li, Kelly A. Ruhn, Brian Hassell, Tess Leal, Sebastian Winter, Ramnik J. Xavier, Lora V. Hooper,

Endoplasmic Reticulum Stress and Disease

Foiling bad bugs' sneaky tricks Intestinal pathogens can invade host cells and disrupt critical cellular functions, including secretion. Secretion is necessary for the delivery of antimicrobial proteins that kill pathogenic bacteria. Bel et al. show that when intestinal epithelial cells sense an invading bacterial pathogen, they “reroute” the antimicrobial protein lysozyme through an alternative autophagy-based secretion pathway (see the Perspective by Kaser and Blumberg). This ensures lysozyme delivery to the gut lumen, which protects against further bacterial invasion. Secretory autophagy was triggered by endoplasmic reticulum stress and required signals from type 3 innate lymphoid cells. Thus, the innate immune response to gut pathogens co-opts autophagy in intestinal immune defense. Science , this issue p. 1047 ; see also p. 976