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O12 Effect of the hexane fraction obtained from the hydroalcoholic extract of Punica granatum leaves on cecal ligation and puncture-induced sepsis in mice

2017; Elsevier BV; Volume: 139; Linguagem: Inglês

10.1016/j.bcp.2017.06.077

1873-2968

Nágila Caroline Fialho Sousa, Isabella Fernandes da Silva Figueiredo, Mizael Calácio Araújo, Elaine Pereira de Andrade, Thaís Costa Alves, Bruna Letícia Rosa da Silva, Domingos Magno Santos Pereira, Saulo José Figueiredo Mendes, João João Francisco Silva Rodrigues, Simone A. Teixeira, André Álvares Marques Vale, Marcus Vinícius Dias-Souza, Lídio Gonçãlves Lima Neto, Vera Lúcia dos Santos, Ana Paula Silva de Azevedo dos Santos, Marcelo N. Muscará, Valério Monteiro‐Neto, Andrea de Souza Monteiro, Luís Cláudio Nascimento da Silva, Elizabeth S. Fernandes,

Pomegranate: compositions and health benefits

Sepsis is characterized by a systemic inflammatory response to infection, associated with high morbidity and mortality. The few effective available drugs have increased the search for novel antimicrobial and anti-inflammatory compounds of natural origin. Punica granatum L. is a plant commonly used in the folk medicine due to its potential anti-inflammatory properties. Recent studies have reported these actions for P. granatum extracts or derived compounds. However, little is known of the effects of P. granatum extracts or fractions. Here, we investigated the actions of a hexane fraction (HF) obtained from the leaf hydroalcoholic extract of this plant in a murine model of sepsis induced by cecal ligation and puncture (CLP). We found that HF (at 100 mg/kg per os) reduces the production of interleukin-6, nitric oxide and hydrogen peroxide in septic mice. HF also increased polymorphonuclear cell accumulation in the peritoneum. Several compounds with known anti-inflammatory actions were detected in HF such as diterpenes, triterpenes and phytosterols. Overall, HF attenuated the release of inflammatory mediators in sepsis in a neutrophil-independent manner. This effect may be associated with its bioactive compounds which may act synergistically or additively, thus, influencing the immunomodulatory activity of HF in vivo.