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Pain in tropical spastic paraparesis: HTLV-I associated myelopathy patients

2009; Thieme Medical Publishers (Germany); Volume: 67; Issue: 4 Linguagem: Inglês

10.1590/s0004-282x2009000600042

1678-4227

Carlos Maurício de Castro‐Costa, Abelardo Araújo, Carlos C. da Camara, Arthur de Sá Ferreira, TEREZINHA J.T. SANTOS, S B Castro-Costa, R N M Acântara, Graham P. Taylor,

T-cell and Retrovirus Studies

abstract – Objective: Tropical Spastic Paraparesis/HTLV-I Associated Myelopathy (TSP/HAM) is a chronic myelopathy, and pain has been mentioned as a frequent sensory symptom in this condition. The authors aimed at analyzing this symptom in a TSP/HAM patients series. Method: For this, 46 patients were analyzed considering demographic and clinical characteristics and complaint of pain as to verbal description, time of onset and classification, correlated with the degree of motor disability and type of pain. Results: Among the 46 TSP/HAM patients, 28 (60.8%) complained of pain, predominant in the early phase of the disease. Most of the patients exhibited neuropathic characteristics of pain, correlated with increased motor disability. Conclusion: Pain in TSP/HAM patients is a frequent and early symptom, and the neuropathic type is predominant (57.1%) and paralleled with increased incapacitation. The pathogenic involvement of cytokines may possibly be involved in the meaning of this symptom in this condition.Key wordS: TSP/HAM, HTLV-I, pain, inflammatory nociceptive and neuropathic, cytokines.dor em pacientes com paraparesia espastica tropical/mielopatia associada ao HTlV-iresumo – Objetivo: A Paraparesia espastica Tropical/Mielopatia Associada ao HTLV-I (PeT/MAH) e uma mielopatia cronica, e a dor tem sido mencionada como um sintoma sensitivo frequente nessa condicao. os autores objetivam analisar esse sintoma numa serie de pacientes com PeT/MAH. Metodo: Para isso, 46 pacientes foram analisados considerando caracteristicas demograficas e clinicas, e queixa de dor do ponto de vista da descricao verbal, tempo de inicio e classificacao, correlacionados com o grau de incapacitacao motora e o tipo de dor. Resultados: dentre os 46 pacientes com PeT/MAH, 28 (60,8%) se queixavam de dor, predominando na fase inicial da doenca. A maioria dos pacientes evidenciou caracteristicas de dor neuropatica, correlacionada com aumento da incapacitacao motora. Conclusao: A dor em pacientes com PeT/MAH e um sintoma frequente e inicial, sendo o tipo neuropatico predominante (57,1%) e em paralelo com maior incapacitacao. o envolvimento patogenico das citocinas podera possivelmente estar relacionado com o significado desse sintoma nessa condicao clinica.PALAVrAS-CHAVe: PeT/MAH, HTLV-I, dor, nociceptiva inflamatoria e neuropatica, citocinas.