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ANALYSIS OF GLYCOLYTIC METABOLISM AND OSTEOCLASTOGENESIS IN GIANT CELL LESIONS OF THE JAW

2017; Elsevier BV; Volume: 124; Issue: 2 Linguagem: Inglês

10.1016/j.oooo.2017.05.341

2212-4411

Patrícia Guerra Peixe Gonçalves, Rodrigo Porpino Mafra, Amanda Katarinny Goes Gonzaga, Rodrigo Gadelha Vasconcelos, Marcelo Gadelha Vasconcelos, Bruno César de Vasconcelos Gurgel, Lélia María Guedes Queiroz,

Sarcoma Diagnosis and Treatment

The aim of this study was to evaluate the immunohistochemical expression of glut transporter type 1 (GLUT-1) and macrophage-colony stimulating factor (M-CSF) in central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL), in an attempt to contribute to a better understanding about the pathogenesis of these lesions. 20 aggressive CGCLs, 20 non-aggressive CGCLs and 20 PGCLs were submitted to immunohistochemical analysis using anti-GLUT-1 and anti-M-CSF antibodies. A semi-quantitative assessment was performed based on intensity and percentage of immunoreactivity mononuclear cells (MCs) and multinuclear giant cells (MGCs). Concerning GLUT-1 expression, the groups showed an increasing gradient in MCs, with lower values for PGCLs, followed by non-aggressive and aggressive CGCLs. For M-CSF, staining intensity in MCs and MGCs showed significant differences between PGCLs and non-aggressive CGCLs, and between non-aggressive and aggressive CGCLs. These findings suggest that GLUT-1 play an important role in providing energy for cell metabolism. Moreover, M-CSF may contribute to osteoclastogenesis and bone resorption mechanism in the studied lesions.