Portal de Periódicos da CAPES

Current diagnostics and treatment of fibrosarcoma -perspectives for future therapeutic targets and strategies

2017; Impact Journals LLC; Volume: 8; Issue: 61 Linguagem: Inglês

10.18632/oncotarget.20136

1949-2553

Daniela Augsburger, Peter J. Nelson, Thomas Kalinski, Andrej Udelnow, Thomas Knösel, Monika Hofstetter, Ji Wei Qin, Yan Wang, Arvid Sen Gupta, Susanne Bonifatius, Minglun Li, Christiane J. Bruns, Yue Zhao,

Bone Tumor Diagnosis and Treatments

// Daniela Augsburger 1 , Peter J. Nelson 2 , Thomas Kalinski 3 , Andrej Udelnow 1 , Thomas Knösel 4 , Monika Hofstetter 2 , Ji Wei Qin 1 , Yan Wang 1 , Arvid Sen Gupta 1 , Susanne Bonifatius 1 , Minglun Li 5 , Christiane J. Bruns 1, 6, 7 and Yue Zhao 1, 6, 7 1 Department of General, Visceral und Vascular Surgery, Otto-von-Guericke University, Magdeburg, Germany 2 Clinical Biochemistry Group, Medizinische Klinik und Poliklinik IV, University of Munich, Munich, Germany 3 Department of Pathology, Otto-von-Guericke University, Magdeburg, Germany 4 Institute of Pathology, Ludwig-Maximilians-University (LMU), Munich, Germany 5 Department of Radiation Oncology, Ludwig-Maximilians-University (LMU), Munich, Germany 6 Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany 7 Present address: Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany Correspondence to: Christiane J. Bruns, email: christiane.bruns@uk-koeln.de Yue Zhao, email: zyberry@gmail.com Keywords: fibrosarcoma, tumor microenvironment, therapeutic resistance, matrix metalloproteinases (MMPs) Received: June 06, 2017 Accepted: July 29, 2017 Published: August 10, 2017 ABSTRACT Adult-type fibrosarcoma is a rare and highly aggressive subtype of soft tissue sarcomas. Due to the existence of other spindle-cell shaped sarcomas, its diagnosis is always one of exclusion. The likelihood of misdiagnoses between similar tumour entities is high, and often leads to inappropriate tumour treatment. We summarize here the main features of fibrosarcoma. When fibrosarcoma is appropriately diagnosed, the patient`s overall prognosis is generally quite poor. Fibrosarcoma is characterized by its low sensitivity towards radio- and chemotherapy as well as by its high rate of tumour recurrences. Thus it is important to identify new methods to improve treatment of this tumour entity. We discuss some promising new directions in fibrosarcoma research, specifically focusing on more effective targeting of the tumour microenvironment. Communication between tumour cells and their surrounding stromal tissue play a crucial role in cancer progression, invasion, metastasis and chemosensitivity. The therapeutic potential of targeting the tumour microenvironment is addressed.