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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder

2017; Volume: 15; Issue: 3 Linguagem: Português

10.9758/cpn.2017.15.3.269

ISSN

2093-4327

Autores

Izabela Guimarães Barbosa, Gabriela Neves Vaz, Natália Pessoa Rocha, Rodrigo Machado‐Vieira, Marcio Rogerio Diniz Ventura, Rodrigo Barreto Huguet, Moisés Evandro Bauer, Michael Berk, Antônio Lúcio Teixeira,

Tópico(s)

Tryptophan and brain disorders

Resumo

Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD.Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA.Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls.These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.

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