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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

2017; Elsevier BV; Volume: 137; Linguagem: Inglês

10.1016/j.toxicon.2017.08.002

ISSN

1879-3150

Autores

Juliana Freire Chagas Vinhote, Dânya Bandeira Lima, Ramon Róseo Paula Pessoa Bezerra de Menezes, Clarissa Perdigão Mello, Bibiana Monson de Souza, Alexandre Havt, Mário Sérgio Palma, Ricardo Santos, E.L. Albuquerque, V. N. Freire, Alice Maria Costa Martins,

Tópico(s)

Antimicrobial Peptides and Activities

Resumo

Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi.

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