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Cardio Vascular Outcomes Trials (CVOTs) with Anti-Hyperglycemic Agents: Demystifying Statistical Complexities

2017; MedCrave Group; Volume: 4; Issue: 4 Linguagem: Inglês

10.15406/jdmdc.2017.04.00116

2374-6947

Samit Ghosal,

Diabetes Management and Research

There is an explosion of cardiovascular outcome trials (CVOTs) in the last decade or so.Each of these studies generated more questions than providing clinically useful answers.The specific aims of the study were blurred by a lot of attention directed towards secondary end points sometimes diverting our attention from the primary hypothesis being tested.One of the principle reasons behind this phenomenon has been our poor understanding of statistical analysis.This drawback resulted in a non-systematic approach to analyzing the CV outcome trial and the resulting confusion.It is after a very long time that endocrinologists and diabetologists have found some meaning to managing diabetes after UKPDS helped us in becoming one.Instead of basking in the glory of the new found treasure and taking it forwards with intense vigor we saw our fraternity going into a shell.Criticism of the data is important as it helps in improving the trial designs further in the long run.However this should not shift our focus away from the robust positive findings at hand.This review attempts at demystifying certain aspects of statistical analysis frequently encountered in CV outcome trial and develop a personal understanding on the same instead of depending on conflicting interpretations floated at different continuing medical educations (CMEs) and Diabetes Congresses.