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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Transplantation of human immature dental pulp stem cell in dogs with chronic spinal cord injury

2017; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 32; Issue: 7 Linguagem: Inglês

10.1590/s0102-865020170070000005

ISSN

1678-2674

Autores

Matheus Levi Tajra Feitosa, Carlos Alberto Palmeira Sarmento, Renato Zonzini Bocabello, Patrícia Cristina Baleeiro Beltrão-Braga, Graciela Conceição Pignatari, C. J. E. M. Fortes, Maria Angélica Miglino, Jéssica Rodrigues Orlandin, Carlos Eduardo Ambrósio,

Tópico(s)

Tissue Engineering and Regenerative Medicine

Resumo

Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation. Conclusion: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy.

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