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Genomic profiling of ER + breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance

2017; American Association for the Advancement of Science; Volume: 9; Issue: 402 Linguagem: Inglês

10.1126/scitranslmed.aai7993

1946-6242

Jennifer M. Giltnane, Katherine E. Hutchinson, Thomas Stricker, Luigi Formisano, Christian D. Young, Mónica V. Estrada, Mellissa J. Nixon, Liping Du, Violeta Sánchez, Paula I. González-Ericsson, María G. Kuba, Melinda E. Sanders, Xinmeng Jasmine Mu, Eliezer M. Van Allen, Nikhil Wagle, Ingrid A. Mayer, Vandana G. Abramson, Henry Gómez, Monica Rizzo, Weiyi Toy, Sarat Chandarlapaty, Erica L. Mayer, Jason Christiansen, Danielle Murphy, Kerry D. Fitzgerald, Kai Wang, Jeffrey S. Ross, Vincent A. Miller, P. J. Stephens, Roman Yelensky, Levi A. Garraway, Yu Shyr, Ingrid M. Meszoely, Justin M. Balko, Carlos L. Arteaga,

Cancer-related Molecular Pathways

Genomic profiling of ER + /HER2 − breast tumors after short-term estrogen deprivation revealed alterations associated with intrinsic resistance and provided mechanistic insights.