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Direct synthesis of 3-halo-3-arylacrylonitriles from the addition of cyanoalkynes with alkaline metal halides

2017; Elsevier BV; Volume: 58; Issue: 37 Linguagem: Inglês

10.1016/j.tetlet.2017.07.104

1873-3581

Zhipeng Guan, Zhiwen Liu, Wei Shi, Hao Chen,

Catalytic Alkyne Reactions

An efficient synthesis of 3-halo-3-arylacrylonitrile is described from the direct addition between cyanoalkynes and inorganic alkaline metal halides such as LiCl, LiBr and KI in good to satisfactory yields. No transition metal is needed for the synthesis of iodo- and bromo-products, although Pd catalyst is used to accelerate the chloro-product.