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First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials

2017; Elsevier BV; Volume: 18; Issue: 9 Linguagem: Inglês

10.1016/s1470-2045(17)30457-6

1474-5488

Harpreet Wasan, Peter Gibbs, Navesh Sharma, Julien Taı̈eb, Volker Heinemann, Jens Ricke, Marc Peeters, Michael Findlay, Andrew Weaver, Jamie Mills, Charles Wilson, Richard Adams, Anne Francis, Joanna Moschandreas, Pradeep S. Virdee, Peter Dutton, Sharon Love, Val Gebski, Alastair Gray, Guy van Hazel, Ricky A. Sharma, Richard Adams, Andrew Bateman, Claire Blesing, Ewan Brown, Ian Chau, Sebastian Cummins, David Cunningham, Stephen Falk, Maher Hadaki, Marcia Hall, Tamas Hickish, Joanne Hornbuckle, F. Lofts, Sarah Lowndes, Astrid Mayer, Matthew S. Metcalfe, Gary Middleton, Jamie Mills, Amir Montazeri, R. Muirhead, Andreas Polychronis, Colin Purcell, Paul J. Ross, Ricky A. Sharma, Liz Sherwin, David Smith, Rubin Soomal, Daniel Swinson, Axel Walther, Harpreet Wasan, Andrew Weaver, Charles Wilson, Greg Wilson, Pradip Amin, Bruna Angelelli, Jacques Balosso, Alex Beny, Daniel Bloomgarden, Evelyn Boucher, Michael D. Brown, Harald-Robert Bruch, James T. Bui, Matthew Burge, Giuseppe Cardaci, James Carlisle, Seungjean Chai, Yi‐Jen Chen, P. Chevallier, Michael D. Chuong, Stephen Clarke, Andrew L. Coveler, M Craninx, Thierry Delanoit, Amélie Deleporte, Paul Eliadis, Francis Facchini, Thomas W. Ferguson, Michel Ferrante, Michael Findlay, Gary Frenette, Jacob Frick, Vinod Ganju, Michael Garofalo, Karen Geboes, Gerald Gehbauer, Benjamin George, Ravit Geva, Peter Gibbs, Melita A. Gordon, Katherine E. Gregory, Seza A. Güleç, James Hannigan, Guy van Hazel, Norman Heching, Volker Heinemann, Thomas Helmberger, Alain Hendlisz, Koen Hendrickx, Matthew P. Holtzman, Richard Isaacs, Christopher Jackson, Philip E. James, Adeel Kaiser, Christos S. Karapetis, Andreas Kaubisch, Yon-Dschun Ko, H. Kröning, Frank Lammert, Winston Liauw, Steven Limentani, Samy Louafi, Marc De Man, Jeffrey Margolis, Robert N. Martin, Andrea Martoni, Gavin Marx, Marco Matos, Els Monsaert, Veerle Moons, Louise Nott, Arnd Nusch, Anne O’Donnell‐Luria, Howard Ozer, Siddarth Padia, Nick Pavlakis, Marc Peeters, D Díaz Pérez, Stefan Pluntke, Marc Polus, Alex Powell, Marc Pracht, Timothy Price, David Ransom, Christine Rebischung, Jens Ricke, Karsten Ridwelski, Jorge Riera‐Knorrenschild, Hanno Riess, William S. Rilling, Bridget A. Robinson, Javier Rodríguez, Federico Augusto Sanchez, Tilmann Sauerbruch, Michael A. Savin, Klemens Scheidhauer, Elyse Schneiderman, Grant R. Seeger, Eva Segelov, Einat Shaham Schmueli, Adi Shani, Jenny Shannon, Navesh Sharma, Stephen Shibata, Nimit Singhal, Denis Smith, Randall Smith, Salomon M. Stemmer, Oliver Stötzer, Andrew Strickland, Julien Taı̈eb, Klaus Tatsch, Eric Terrebonne, Thomas Tichler, Ursula Vehling‐Kaiser, Ruth Vera, Thomas Vogl, Euan Walpole, Eric Wang, Samuel H. Whiting, Ido Wolf, Steven Ades, Morteza Aghmesheh, Bruna Angelelli, Miklos Auber, Hubert Ayala, Alex Beny, Daniel Bloomgarden, Patrick A. Boland, Eveline Bouche, Charles Bowers, Christoph Bremer, James T. Bui, Mathew Burge, James Carlisle, Ana Ruiz‐Casado, Seungjean Chai, Michael D. Chuong, Prasad Cooray, M Christ Crain, Maike de Wit, Kyran Dowling, Aurélie Durand, Francis Facchini, Sandrine Faivre, Kynan Feeney, Tom Ferguson, Aurélie Ferru, Michael Findlay, Maria Candida Barisson Villares Fragoso, Gary Frenette, Jacob Frick, Vinod Ganju, Ravit Geva, Peter Gibbs, Cristina Granetto, Pascal Hammel, Guy van Hazel, Norman Heching, Alain Hendlisz, Koen Hendrickx, Matthew P. Holtzman, Richard Issacs, Renuka Iyer, Christopher Jackson, Adeel Kaiser, Andreas Kaubisch, Yeul Hong Kim, H. Kröning, Jin‐Tung Liang, Lionel Lim, Steven Limentani, Liu H, Samy Louafi, Marc De Man, Gianluca Masi, Marco Matos, Els Monsaert, Stefania Mosconi, Louise Nott, Gianmauro Numico, Anne O’Donnell‐Luria, Marc Peeters, Marc Polus, Marc Pracht, Lynn Ratner, Christine Rebischung, Han Sae-Won, Federico Augusto Sanchez, Adi Shani, Navesh Sharma, Madhu Singh, Nimit Singhal, Denis Smith, Patricia Stoltzfus, Andrew Strickland, Julien Taı̈eb, Iain Tan, Eric Terrebonne, Thomas Tichler, Antonio Trogu, Craig Underhill, Ruth Vera, Euan Walpole, Eric Wang, Mark Westcott,

Pancreatic and Hepatic Oncology Research

Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resin microspheres in patients with metastatic colorectal cancer with liver metastases. The studies were designed for combined analysis of overall survival.