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pH- and temperature-induced release of doxorubicin from multilayers of poly(2-isopropyl-2-oxazoline) and tannic acid

2017; Wiley; Volume: 66; Issue: 12 Linguagem: Inglês

10.1002/pi.5458

1097-0126

Meltem Haktanıyan, Suleyman Atilla, Eda Cagli, Irem Erel‐Göktepe,

Electrospun Nanofibers in Biomedical Applications

Polymer InternationalVolume 66, Issue 12 p. 1851-1863 Research Article pH- and temperature-induced release of doxorubicin from multilayers of poly(2-isopropyl-2-oxazoline) and tannic acid Meltem Haktaniyan, Meltem Haktaniyan Department of Chemistry, Middle East Technical University, Cankaya, Ankara, TurkeySearch for more papers by this authorSuleyman Atilla, Suleyman Atilla Department of Chemistry, Middle East Technical University, Cankaya, Ankara, TurkeySearch for more papers by this authorEda Cagli, Eda Cagli Department of Chemistry, Middle East Technical University, Cankaya, Ankara, TurkeySearch for more papers by this authorIrem Erel-Goktepe, Corresponding Author Irem Erel-Goktepe erel@metu.edu.tr orcid.org/0000-0001-7856-7160 Department of Chemistry, Middle East Technical University, Cankaya, Ankara, TurkeyCorrespondence to: I Erel-Goktepe, Department of Chemistry, Middle East Technical University, 06800, Cankaya, Ankara, Turkey. E-mail: erel@metu.edu.trSearch for more papers by this author Meltem Haktaniyan, Meltem Haktaniyan Department of Chemistry, Middle East Technical University, Cankaya, Ankara, TurkeySearch for more papers by this authorSuleyman Atilla, Suleyman Atilla Department of Chemistry, Middle East Technical University, Cankaya, Ankara, TurkeySearch for more papers by this authorEda Cagli, Eda Cagli Department of Chemistry, Middle East Technical University, Cankaya, Ankara, TurkeySearch for more papers by this authorIrem Erel-Goktepe, Corresponding Author Irem Erel-Goktepe erel@metu.edu.tr orcid.org/0000-0001-7856-7160 Department of Chemistry, Middle East Technical University, Cankaya, Ankara, TurkeyCorrespondence to: I Erel-Goktepe, Department of Chemistry, Middle East Technical University, 06800, Cankaya, Ankara, Turkey. E-mail: erel@metu.edu.trSearch for more papers by this author First published: 12 August 2017 https://doi.org/10.1002/pi.5458Citations: 17Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract We present a simple strategy to prepare doxorubicin (DOX) containing hydrogen-bonded films of poly(2-isopropyl-2-oxazoline) (PIPOX) and tannic acid (TA) which release DOX in acidic conditions while releasing a minimal amount of DOX at physiological pH. Water soluble complexes of TA and DOX (TA − DOX) were prepared prior to film construction. PIPOX and TA − DOX were deposited at the surface at pH 6.5 using the layer-by-layer (LbL) technique. We found that multilayers released a minimal amount of DOX at physiological pH due to further ionization of TA with increasing pH and enhanced electrostatic interactions between TA and DOX. In contrast, pH-induced release of DOX was observed in moderately acidic conditions due to protonation of TA as the acidity increased and electrostatic interactions between TA and DOX decreased. Moreover, we found that raising the temperature from 25 °C to 37.5 °C increased the amount of DOX released from the surface. This can be rationalized with the conformational changes within the multilayers correlated with the lower critical solution temperature behaviour of PIPOX and increased kinetic energy of DOX molecules. Considering the acidic nature of tumour tissues and important biological properties of PIPOX and TA, these multilayers are promising for pH- and temperature-triggered release of DOX from surfaces. © 2017 Society of Chemical Industry Citing Literature Supporting Information Filename Description pi5458-sup-0001-suppinfo.docxWord 2007 document , 728.1 KB Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume66, Issue12December 2017Pages 1851-1863 RelatedInformation