Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε‐4 allele

2017; Wiley; Volume: 33; Issue: 2 Linguagem: Inglês

10.1002/gps.4773

1099-1166

Marco Túlio Gualberto Cintra, Rafaela Ávila, Thayana Oliveira Soares, Luciana Cristina Matos Cunha, Kátia D. Silveira, Edgar Nunes de Moraes, Kaique Simas, Renato Bragança Fernandes, Denise Utsch Gonçalves, Nilton Alves de Rezende, Maria Aparecida Camargos Bicalho,

Dementia and Cognitive Impairment Research

Objective To compare the results of neuropsychological tests, evoked potentials N200 and P300 and polymorphisms of ApoE and BDNF rs6265 between patients with normal cognition and those with mild cognitive impairment (MCI) and Alzheimer's dementia (AD). Methods This is a cross‐sectional study of elderly individuals with normal cognition and those with MCI and AD, who were submitted to evoked potential tests (N200 and P300) by means of hearing stimuli based on the auditory oddball paradigm. Genotyping was obtained by using the real‐time PCR technique. Results Sixty‐five patients were evaluated as follows: 14 controls, 34 with MCI and 17 with AD. N200 latency and P300 latency and amplitude were not associated with MCI and AD diagnosis. Patients with cognitive impairment (MCI or AD) showed increase in the latencies of P300 and N200. BNDF gene was not associated with cognitive impairment. Conclusion Latencies of N200 and P300 increased in cognitively impaired patients with the presence of ApoE ε‐4 allele.