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TCTN2: a novel tumor marker with oncogenic properties

2017; Impact Journals LLC; Volume: 8; Issue: 56 Linguagem: Inglês

10.18632/oncotarget.20438

1949-2553

David Cano-Rodríguez, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Elisa De Camilli, Chaojun Song, Boquan Jin, Aurélien Lacombe, Andrea Pierleoni, Mauro Bombaci, Chiara Cordiglieri, Marcel H.J. Ruiters, Giuseppe Viale, Luigi Terracciano, Paolo Sarmientos, Sergio Abrignani, Guido Grandi, Piero Pileri, Marianne G. Rots, Renata Grifantini,

Tumors and Oncological Cases

Tectonic family member 2 (TCTN2) encodes a transmembrane protein that belongs to the tectonic family, which is involved in ciliary functions. Previous studies have demonstrated the role of tectonics in regulating a variety of signaling pathways at the transition zone of cilia. However, the role of tectonics in cancer is still unclear. Here we identify that TCTN2 is overexpressed in colorectal, lung and ovary cancers. We show that different cancer cell lines express the protein that localizes at the plasma membrane, facing the intracellular milieu. TCTN2 over-expression in cancer cells resulted in an increased ability to form colonies in an anchorage independent way. On the other hand, downregulation of TCTN2 using targeted epigenetic editing in cancer cells significantly reduced colony formation, cell invasiveness, increased apoptosis and impaired assembly of primary cilia. Taken together, our results indicate that TCTN2 acts as an oncogene, making it an interesting cancer-associated protein and a potential candidate for therapeutic applications.