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Measles Virus Neutralizing Antibodies in Intravenous Immunoglobulins: Is an Increase by Revaccination of Plasma Donors Possible?

2017; Oxford University Press; Volume: 216; Issue: 8 Linguagem: Inglês

10.1093/infdis/jix428

1537-6613

Jens Modrof, Björn Tille, Maria R. Farcet, John McVey, Jessica Schreiner, Charles M Borders, Maria Gudino, Peter Fitzgerald, Toby L. Simon, Thomas R. Kreil,

Parvovirus B19 Infection Studies

We report a screen of plasma donors confirming that widespread use of childhood measles vaccination since 1963 resulted in a decrease in average measles virus antibody titers among plasma donors, which is reflected in intravenous immunoglobulins (IVIGs). The measles virus antibody titer, however, is a potency requirement for IVIGs, as defined in a Food and Drug Administration regulation. To mitigate the decline in measles virus antibody titers in IVIGs and to ensure consistent product release, revaccination of plasma donors was investigated as a means to boost titers. However, revaccination-induced titer increases were only about 2-fold and short-lived.