Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC-Spain Study
2017; Lippincott Williams & Wilkins; Volume: 199; Issue: 2 Linguagem: Inglês
10.1016/j.juro.2017.08.087
ISSN1527-3792
AutoresAdela Castelló, Elena Boldo, Pilar Amiano, Gemma Castaño‐Vinyals, Núria Aragonés, Inés Gómez‐Acebo, Rosana Peiró, José Juan Jiménez‐Moleón, Juan Alguacil, Adonina Tardón, Lluís Cecchini, Virginia Lope, Trinidad Dierssen‐Sotos, Lourdes Mengual, Manolis Kogevinas, Marina Pollán, Beatriz Pérez‐Gómez,
Tópico(s)Colorectal Cancer Screening and Detection
ResumoNo AccessJournal of UrologyAdult Urology1 Feb 2018Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC-Spain Study Adela Castelló, Elena Boldo, Pilar Amiano, Gemma Castaño-Vinyals, Nuria Aragonés, Inés Gómez-Acebo, Rosana Peiró, Jose Juan Jimenez-Moleón, Juan Alguacil, Adonina Tardón, Lluís Cecchini, Virginia Lope, Trinidad Dierssen-Sotos, Lourdes Mengual, Manolis Kogevinas, Marina Pollán, Beatriz Pérez-Gómez, and MCC-Spain Researchers Adela CastellóAdela Castelló Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain , Elena BoldoElena Boldo Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain , Pilar AmianoPilar Amiano Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Public Health Division of Gipuzkoa, BioDonostia Research Health Institute, San Sebastian, Spain , Gemma Castaño-VinyalsGemma Castaño-Vinyals ISGlobal, Centre for Research in Environmental Epidemiology, Barcelona, Spain Medical Research Institute, Barcelona, Spain Universitat Pompeu Fabra, Barcelona, Spain , Nuria AragonésNuria Aragonés Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain , Inés Gómez-AceboInés Gómez-Acebo Universidad de Cantabria-IDIVAL, Santander, Spain , Rosana PeiróRosana Peiró Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO-Salud Pública, Valencia, Spain , Jose Juan Jimenez-MoleónJose Juan Jimenez-Moleón Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Instituto de Investigación Biosanitaria de Granada and Department of Preventive Medicine and Public Health, School of Medicine. University of Granada, Granada, Spain , Juan AlguacilJuan Alguacil Centro de Investigación en Salud y Medio Ambiente. Universidad de Huelva, Huelva, Spain , Adonina TardónAdonina Tardón Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain , Lluís CecchiniLluís Cecchini Urology Department, Hospital del Mar, Barcelona, Spain , Virginia LopeVirginia Lope Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain , Trinidad Dierssen-SotosTrinidad Dierssen-Sotos Universidad de Cantabria-IDIVAL, Santander, Spain , Lourdes MengualLourdes Mengual Laboratory and Department of Urology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain Centre de Recerca Biomèdica CELLEX, Barcelona, Spain , Manolis KogevinasManolis Kogevinas ISGlobal, Centre for Research in Environmental Epidemiology, Barcelona, Spain Medical Research Institute, Barcelona, Spain Universitat Pompeu Fabra, Barcelona, Spain , Marina PollánMarina Pollán Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain , Beatriz Pérez-GómezBeatriz Pérez-Gómez Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain , and MCC-Spain Researchers View All Author Informationhttps://doi.org/10.1016/j.juro.2017.08.087AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We explored the association of the previously described Western, prudent and Mediterranean dietary patterns with prostate cancer risk by tumor aggressiveness and extension. Materials and Methods: MCC-Spain (Multicase-Control Study on Common Tumors in Spain) is a population based, multicase-control study that was done in 7 Spanish provinces between September 2008 and December 2013. It collected anthropometric, epidemiological and dietary information on 754 histologically confirmed incident cases of prostate cancer and 1,277 controls 38 to 85 years old. Three previously identified dietary patterns, including Western, prudent and Mediterranean, were reconstructed using MCC-Spain data. The association of each pattern with prostate cancer risk was assessed by logistic regression models with random, province specific intercepts. Risk according to tumor aggressiveness (Gleason score 6 vs greater than 6) and extension (cT1-cT2a vs cT2b-cT4) was evaluated by multinomial regression models. Results: High adherence to a Mediterranean dietary pattern rich not only in fruits and vegetables but also in fish, legumes and olive oil was specifically associated with a lower risk of Gleason score greater than 6 prostate cancer (quartile 3 vs 1 relative RR 0.66, 95% CI 0.46–0.96 and quartile 4 vs 1 relative RR 0.68, 95% CI 0.46–1.01, p-trend = 0.023) or with higher clinical stage (cT2b-T4 quartile 4 vs 1 relative RR 0.49, 95% CI 0.25–0.96, p-trend = 0.024). This association was not observed with the prudent pattern, which combines vegetables and fruits with low fat dairy products, whole grains and juices. The Western pattern did not show any association with prostate cancer risk. Conclusions: Nutritional recommendations for prostate cancer prevention should consider whole dietary patterns instead of individual foods. 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Volume 199Issue 2February 2018Page: 430-437Supplementary Materials Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.KeywordsMediterraneanprevention & controldietprostatic neoplasmsriskprincipal component analysisMetricsAuthor Information Adela Castelló Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain More articles by this author Elena Boldo Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain More articles by this author Pilar Amiano Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Public Health Division of Gipuzkoa, BioDonostia Research Health Institute, San Sebastian, Spain More articles by this author Gemma Castaño-Vinyals ISGlobal, Centre for Research in Environmental Epidemiology, Barcelona, Spain Medical Research Institute, Barcelona, Spain Universitat Pompeu Fabra, Barcelona, Spain More articles by this author Nuria Aragonés Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain More articles by this author Inés Gómez-Acebo Universidad de Cantabria-IDIVAL, Santander, Spain More articles by this author Rosana Peiró Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO-Salud Pública, Valencia, Spain More articles by this author Jose Juan Jimenez-Moleón Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Instituto de Investigación Biosanitaria de Granada and Department of Preventive Medicine and Public Health, School of Medicine. University of Granada, Granada, Spain More articles by this author Juan Alguacil Centro de Investigación en Salud y Medio Ambiente. Universidad de Huelva, Huelva, Spain More articles by this author Adonina Tardón Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain More articles by this author Lluís Cecchini Urology Department, Hospital del Mar, Barcelona, Spain More articles by this author Virginia Lope Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain More articles by this author Trinidad Dierssen-Sotos Universidad de Cantabria-IDIVAL, Santander, Spain More articles by this author Lourdes Mengual Laboratory and Department of Urology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain Centre de Recerca Biomèdica CELLEX, Barcelona, Spain More articles by this author Manolis Kogevinas ISGlobal, Centre for Research in Environmental Epidemiology, Barcelona, Spain Medical Research Institute, Barcelona, Spain Universitat Pompeu Fabra, Barcelona, Spain More articles by this author Marina Pollán Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain More articles by this author Beatriz Pérez-Gómez Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain Consortium for Biomedical Research in Epidemiology and Public Health, Instituto de Salud Carlos III, Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain More articles by this author MCC-Spain Researchers More articles by this author Expand All Advertisement PDF downloadLoading ...
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