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Thyroid hormones decrease the proinflammatory TLR4/NF-κβ pathway and improve functional parameters of the left ventricle of infarcted rats

2017; Elsevier BV; Volume: 461; Linguagem: Inglês

10.1016/j.mce.2017.09.003

1872-8057

Alexandre Luz de Castro, Rafael Oliveira Fernandes, Vanessa Duarte Ortiz, Cristina Campos Carraro, Jéssica Hellen Poletto Bonetto, Tânia Regina Gattelli Fernandes, Adriana Conzatti, Rafaela Siqueira, Ângela Maria Vicente Tavares, Adriane Belló‐Klein, Alex Sander da Rosa Araújo,

NF-κB Signaling Pathways

Myocardial infarction leads to oxidative stress and promotes activation of the TLR4/NF-κβ proinflammatory pathway. Thyroid hormones (TH) are known to be cardioprotective after infarction. However, there are no studies evaluating whether TH could modulate this pathway in the heart. This study aimed to verify the effect of thyroid hormones on the TLR4/NF-κβ pathway after myocardial infarction. Male Wistar rats were allocated into the following groups: Sham-operated (SHAM), sham-operated + TH (SHAMT), infarcted (AMI) and infarcted + TH (AMIT). The treated rats received T4 and T3 (8 and 2 μg 100 g−1 day−1) for 12 days by gavage. Subsequently, the animals were evaluated by echocardiography and euthanized, and the left ventricle was collected for biochemical and molecular analyses. TH modulates TLR4/NF-κβ expression in the infarcted hearts of rats and decreases xanthine oxidase expression. These effects were related to cardiac functional improvement after infarction. The cardioprotective effects of T3 and T4 seem to involve an anti-inflammatory action.