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Chitosan/kaolin composite porous microspheres with high hemostatic efficacy

2017; Elsevier BV; Volume: 177; Linguagem: Inglês

10.1016/j.carbpol.2017.08.131

1879-1344

Xun Sun, Zonghao Tang, Meng Pan, Zhengchao Wang, Hongqin Yang, Haiqing Liu,

Surgical Sutures and Adhesives

The hemostatic performance of chitosan was greatly improved by blending it with kaolin to fabricate porous composite microspheres (CSMS-K) through inverse emulsion method combining with thermally induced phase separation. The CSMS-K had high amount of interior and surface pores. The synergetic hemostatic competence of chitosan and kaolin components made the hemostatic efficacy of CSMS-K superior to chitosan porous microspheres (CSMS). The hemostatic time of CSMS-K3 in the rat tail amputation and liver laceration models was down to respective 120 and 99 s from 183 and 134 s of CSMS, and the blood loss of CSMS-K3 was respectively 65% and 36% of that of CSMS in the rat tail amputation and liver laceration models. The whole blood clotting kinetics proved that CSMS-K3 formed larger blood clots than CSMS and Celox within a same time period. Our results suggested that the CSMS-K is a potential quick pro-coagulant agent for traumatic hemorrhaging control.