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Hodgkin's Lymphoma in Crohn's Disease Treated with Infliximab

2017; Karger Publishers; Volume: 24; Issue: 6 Linguagem: Inglês

10.1159/000455180

2341-4545

Diana Carvalho, Pedro Russo, Carlos Bernardes, Joana Saiote, Gonçalo Ramos, Luís Paulo Gomes Mascarenhas, Nuno Borges, Jaime Ramos,

Chronic Lymphocytic Leukemia Research

<b><i>Introduction:</i></b> Lymphoproliferative disorders, particularly non-Hodgkin's and Hodgkin's lymphomas, are rare in patients with inflammatory bowel diseases. The use of thiopurines and infection by Epstein-Barr virus are well-known cofactors that can raise its prevalence. Other risk factors such as disease activity and biological treatment are the subject of discussion, without enough data in the literature to confirm a potential association. <b><i>Methods:</i></b> We report a case of Hodgkin's lymphoma in a patient who had been treated with azathioprine and was on long-term monotherapy with infliximab. <b><i>Conclusions:</i></b> We stress the importance of recognizing the possible occurrence of a lymphoproliferative disorder in association with anti-tumor necrosis factor-α therapy