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Topological Defects in Hyperbranched Glycopolymers Enhance Binding to Lectins

2017; Wiley; Volume: 23; Issue: 62 Linguagem: Inglês

10.1002/chem.201703432

1521-3765

Míriam Salvadó, José J. Reina, Javier Rojo, Sergio Castillón, Omar Boutureira,

RNA Interference and Gene Delivery

Central scaffold topology and carbohydrate density are important features in determining the binding mechanism and potency of synthetic multivalent of poly- versus monodisperse carbohydrate systems against a model plant toxin (Ricinus communis agglutinin (RCA120 )). Lower densities of protein receptors favour the use of heterogeneous, polydisperse glycoconjugate presentations, as determined by surface plasmon resonance and dynamic light scattering.