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Synthesis of methylprednisolone loaded ibuprofen modified dextran based nanoparticles and their application for drug delivery in acute spinal cord injury

2017; Impact Journals LLC; Volume: 8; Issue: 59 Linguagem: Inglês

10.18632/oncotarget.20649

1949-2553

Lei S. Qi, Haiyan Jiang, Xiaohui Cui, Guiwen Liang, Ming Gao, Zhongwei Huang, Qinghua Xi,

Nanoparticle-Based Drug Delivery

// Lei Qi 1, * , Haiyan Jiang 1, * , Xiaohui Cui 1 , Guiwen Liang 2 , Ming Gao 3 , Zhongwei Huang 1 and Qinghua Xi 4 1 Department of Emergency Medicine, Affiliated Hospital of Nantong University, Jiangsu, China 2 Department of Geriatric Medicine, Affiliated Hospital of Nantong University, Jiangsu, China 3 Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China 4 Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Jiangsu, China * These authors have contributed equally to this work Correspondence to: Zhongwei Huang, email: hzw889@163.com Qinghua Xi, email: ntdxfsyyxqh@163.com Lei Qi, email: ntdxfsyyql@163.com Haiyan Jiang, email: lansyne@163.com Keywords: methylprednisolone, nanoparticle, drug delivery, drug nanocarrier, acute spinal cord injury Received: April 11, 2017 Accepted: July 25, 2017 Published: September 05, 2017 ABSTRACT To improve the therapeutic efficacy of spinal cord injury (SCI), the methylprednisolone was incorporated into nanoparticles based on the ibuprofen modified dextran. The ibuprofen modified dextran was synthesized using a direct esterification linkage between the carboxylic acids of hydrophobic drug and the hydroxyl groups of the polymer backbone. The morphology of methylprednisolone loaded nanoparticles was evaluated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The therapeutic efficacy of the prepared nanoparticles on the acute SCI model rats was assessed. It is demonstrated that methylprednisolone loaded ibuprofen modified dextran based nanoparticles (MP-loaded NPs) could promote the recovery of neurological deficits, enhance growth of neurons, decrease degeneration of injuried neurons and reduce the tissue tumor necrosis factor alpha (TNF-α) levels significantly in the SCI rats. Subsequently, the study indicates that synthesis of methylprednisolone loaded ibuprofen modified dextran based nanoparticles has a great potential in the synergetic effect treatment for spinal cord injury and nanoparticles based drug delivery system will become a powerful weapon of human conquest of disease.